General
Preferred name
NITRAZEPAM
Synonyms
Nitrazepam-d5 ()
Ro-45360 ()
N05CD02 ()
Benzalin ()
Remnos ()
RO-4-5360 ()
Ro-53059 ()
Nitrazepamum ()
RO 5-3059 ()
Unisomnia ()
NSC-58775 ()
Somnite ()
Nitrados ()
RO 4-5360 ()
RO-5-3059 ()
Mogadon ()
Nitrazepam-d5 (exempt preparation) ()
P&D ID
PD003070
CAS
146-22-5
136765-45-2
Tags
drug
available
Drug indication
Insomnia
Epilepsy
Drug Status
approved
investigational
Max Phase
3.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
MOA Nitrazepam belongs to a group of medicines called benzodiazepines. This drug affects central benzodiazepine receptors, which are associated with inhibitory GABA (gamma amino butyric acid)receptors, leading to enhanced GABA binding activity. GABA is a major neurotransmitter in the brain, which causes somnolence, relaxation of muscles, a decrease in anxiety and general central nervous system depression. Nitrazepam has anticonvulsant properties that may be attributed to its ability to bind to voltage-dependent sodium channels. Sustained repetitive firing seems to be limited by benzodiazepines effect of slowing recovery of sodium channels from inactivation.
TOXICITY An overdose of nitrazepam may lead to impaired breathing, dizziness, decreased cognition and balance, bluish nails and lips, slurred speech, and extreme somnolence, among others. In severe overdose, these symptoms may progress to a coma with a possibility of death.
Compound Sets
13
Cayman Chemical Bioactives
16197
38139
16196
ChEMBL Drugs
CHEMBL13209
DrugBank
DB01595
DrugBank Approved Drugs
DB01595
DrugCentral
1945
DrugCentral Approved Drugs
1945
DrugMAP
DMEGIQ6
DrugMAP Approved Drugs
DMEGIQ6
DrugMatrix
Ki Database
Nitrazepam
NIH Clinical Collections (NCC)
NPC Screening Collection
ReFrame library
External IDs
34
Properties
(calculated by RDKit )
Molecular Weight
281.08
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
2
Ring Count
3
Aromatic Ring Count
2
cLogP
2.38
TPSA
84.6
Fraction CSP3
0.07
Chiral centers
0.0
Largest ring
7.0
QED
0.68
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Therapeutic Class
Antianxiety Agents
Source data