General
Preferred name
cephalexin
Synonyms
cefalexin ()
Cephacillin ()
Cephalexin monohydrate ()
CEPHALEXIN ANHYDROUS ()
CEPHALEXIN HYDRATE ()
Cephalexin (hydrochloride) ()
Cephalexin (monohydrate) ()
CEPHALEXIN HYDROCHLORIDE ()
Cefalexin hydrochloride ()
Cephacillin hydrochloride ()
Cefalexin hydrate ()
Cephacillin hydrate ()
66873 ()
Keftab ()
Keflex ()
Keflet ()
Cephalexin ()
Panixine Disperdose ()
Cefalexin monohydrate ()
Cefanex ()
Kiflone ()
LY-66873 ()
NSC-758162 ()
Tenkorex ()
Ceporex ()
Novolexin ()
Biocef ()
Cephalexin hcl ()
LY061188 ()
LY-061188 ()
P&D ID
PD003054
CAS
15686-71-2
14101-75-8
23325-78-2
105879-42-3
59695-59-9
Tags
covalent binder
natural product
drug
available
Approved by
FDA
First approval
1971
1987
Drug Status
investigational
approved
vet_approved
Drug indication
Bacterial infection
Antibacterial
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
ROE
Cephalexin is over 90% excreted in the urine after 6 hours[A179026] by glomerular filtration and tubular secretion[Label,L6550,L6553] with a mean urinary recovery of 99.3%.[A179032] Cephalexin is unchanged in the urine.[A179026,A179029,A179032]
PHARMACODYNAMICS
Cephalexin (also called Cefalexin) is a first generation cephalosporin antibiotic.[A179071,A179074] It is one of the most widely prescribed antibiotics, often used for the treatment of superficial infections that result as complications of minor wounds or lacerations.[Label] It is effective against most gram-positive bacteria through its inihibition of the cross linking reaction between N-acetyl muramicacid and N-acetylglucosamine in the cell wall, leading to cell lysis.[A179083]
INDICATION
Cephalexin is indicated for the treatment of certain infections caused by susceptible bacteria.[Label,L6550,L6553] These infections include respiratory tract infections, otitis media, skin and skin structure infections, bone infections, and genitourinary tract infections.[Label,L6550,L6553]
MOA
Cephalexin is a first generation cephalosporin antibiotic.[A179071,A179074] Cephalosporins contain a beta lactam and dihydrothiazide.[A179071] Unlike penicillins, cephalosprins are more resistant to the action of beta lactamase.[A179071] Cephalexin inhibits bacterial cell wall synthesis, leading breakdown and eventualy cell death.[Label]
HALF-LIFE
The half life of cephalexin is 49.5 minutes in a fasted state and 76.5 minutes with food though these times were not significantly different in the study.[A179032]
TOXICITY
Symptoms of overdose include blood in the urine, diarrhea, nausea, upper abdominal pain, and vomiting.[Label] An overdose is generally managed through supportive treatment as diuresis, dialysis, hemodialysis, and charcoal hemoperfusion are not well studied in this case.[Label]; ; The oral median lethal dose of cephalexin in rats is >5000 mg/kg. The oral LD50 in a monkey is >1g/kg and the lowest dose causing a toxic effect in humans is 14mg/kg.[MSDS]; ; Cephalexin has not been shown to be harmful in pregnancy and is not associated with teratogeniticy.[Label] Cephalexin is present in breast milk, though infants may be exposed to <1% of the dose given to the mother.[Label] The effects of breast milk exposure to cephalexin have not been established and so caution must be exercised and the risk and benefit of cephalexin use in breastfeeding must be weighed.[Label]; ; Cephalexin has not been studied for carcinogenicity or mutagenicity.[Label] Cephalexin has no affect on fertility in rats.[Label]
ABSORPTION
Well absorbed from the upper gastrointestinal tract with nearly 100% oral bioavailability.[A179032,A179035] Cephalexin is not absorbed in the stomach but is absorbed in the upper intestine.[A179065]; ; Patients taking 250mg of cephalexin reach a maximum plasma concentration of 7.7mcg/mL and patients taking 500mg reach 12.3mcg/mL.[A179026]
METABOLISM
Cephalexin is not metabolized in the body.[A179029,Label,L6550,L6553]
DESCRIPTION
Cephalexin is a cephalosporin antibacterial.
(GtoPdb)
DESCRIPTION
Cefalexin hydrochloride is a cephalosporin antibiotic. It is a first-generation cephalosporin antibiotic introduced in 1967 by Eli Lilly and Company. It is an orally administered agent with a similar antimicrobial spectrum to the intravenous agents cefalotin and cefazolin.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
2
Compound Sets
26
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
CovBinderInPDB
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
NCATS Inxight Approved Drugs
NIH Clinical Collections (NCC)
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
85
Molecular Weight
347.09
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
3
Rotatable Bonds
4
Ring Count
3
Aromatic Ring Count
1
cLogP
0.44
TPSA
112.73
Fraction CSP3
0.31
Chiral centers
3.0
Largest ring
6.0
QED
0.68
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Microbiology&virology
Anti-infection
Target
PBPs
antibiotic
Bacterial
Penicillin-binding protein (PBP)
Antibiotics,Bacterial
MOA
Antibacterial
bacterial cell wall synthesis inhibitor
Disease Area
infectious disease, otolaryngology
Indication
respiratory tract infections, otitis, skin infections, bone and joint infections, genitourinary tract infections
Therapeutic Class
Antibiotics
Source data
