General
Preferred name
CLOBENPROPIT
Synonyms
Clobenpropit dihydrobromide ()
Clobenpropit (dihydrobromide) ()
Clobenpropit (hydrobromide) ()
P&D ID
PD003045
CAS
145231-35-2
145231-45-4
Tags
drug candidate
natural product
biased GPCR ligand
available
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Clobenpropit (dihydrobromide) is a highly potent H3 receptor antagonist and H4 receptor partial agonist. (GtoPdb)
DESCRIPTION Highly selective non-peptide delta agonist (Tocris Bioactive Compound Library)
DESCRIPTION Highly potent H3 antagonist and H4 partial agonist (Tocriscreen Total)
Compound Sets
17
Axon Medchem Screening Library
1209
BiasDB
Clobenpropit
Cayman Chemical Bioactives
10011126
Concise Guide to Pharmacology 2017/18
1223
Concise Guide to Pharmacology 2019/20
1223
Concise Guide to Pharmacology 2021/22
1223
Concise Guide to Pharmacology 2023/24
1223
Drug Repurposing Hub
DrugMAP
DM537OH
DrugMatrix
Guide to Pharmacology
1223
Ki Database
Clobenpropit
MedChem Express Bioactive Compound Library
HY-101198
NIH Clinical Collections (NCC)
TargetMol Bioactive Compound Library
T8439
Tocris Bioactive Compound Library
0752
Tocriscreen Total
External IDs
40
Properties
(calculated by RDKit )
Molecular Weight
308.09
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
3
Rotatable Bonds
6
Ring Count
2
Aromatic Ring Count
2
cLogP
3.45
TPSA
64.56
Fraction CSP3
0.29
Chiral centers
0.0
Largest ring
6.0
QED
0.43
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
GPCR/G protein
Immunology/Inflammation
Neuroscience
Apoptosis
Neuronal Signaling
Target
H3 receptor
HRH1, HRH2, HRH3, HRH4
H3 antagonist
Histamine Receptor
Primary Target
Histamine H3 Receptors
MOA
Antagonist
Histamine Receptor antagonist
Source data