General
Preferred name
clopidogrel
Synonyms
CLOPIDOGREL SULFATE ()
(S)-(+)-Clopidogrel bisulfate ()
SR-25990C ()
(S)-(+)-Clopidogrel hydrogen sulfate ()
(S)-Clopidogrel ()
(+)-Clopidogrel hydrogen sulfate ()
Plavix ()
clopidogrel hydrogensulfate ()
Clopidogrel bisulfate ()
Clopidogrel (hydrogen sulfate) ()
Clopidogrelum ()
SR-25990C, Clopidogrel hydrogen sulfate, Iscover, Plavix ()
Clopidogrel (SR-25990C) Bisulfate ()
Clopidogrel hydrogen sulfate ()
CLOPIDOGREL HYDROBROMIDE ()
CLOPIDOGREL BISULFATE ()
CLOPIDOGREL BESILATE ()
CLOPIDOGREL HYDROCHLORIDE ()
(S)-(+)-Clopidogrel (sulfate) ()
Clopidogrel hydrogen sulphate ()
Clopidogrel sulfate ()
Clopidogrel ratiopharm ()
Clopidogrel bgr (previously zylagren) ()
Clopidogrel bisulphate ()
Clopidogrel (as hydrogen sulfate) ()
Clopidogrel teva (hydrogen sulphate) ()
Isocover ()
Clopidogrel bisulfate component of duoplavin ()
Clopidogrel bms ()
Clopidogrel zentiva ()
Clopidogrel teva ()
Zyllt ()
Clopidogrel bisulfate component of duocover ()
Clopidogrel bisulfate component of clopidogrel/acetylsalicyclic acid teva ()
Clopidogrel (as bisulfate) ()
Clopidogrel-bgr ()
Pidogrel ()
Iscover ()
Clopidogrel zentiva (previously clopidogrel winthrop) ()
Clopidogrel-bms ()
SR 25990C ()
R-130964 ()
SR-25990 ()
NSC-758613 ()
R 130964 ()
SR 25990 ()
(S)-(+)-Clopidogrel-d3 (sulfate) ()
Clopidogrel 1a-pharma ()
Clopidogrel apotex ()
Clopidogrel besylate ()
Clopidogrel 1a pharma ()
Clopidogrel viatris (previously clopidogrel taw pharma) ()
Grepid ()
Clopidogrel acino ()
Clopidogrel-ratiopharm ()
Clopidogrel acino pharma ()
Clopidogrel sandoz ()
Clopidogrel hexal ()
Clopidogrel ratiopharm gmbh ()
Clopidogrel acino pharma gmbh ()
Clopidogrel besilate ()
Clopidogrel teva pharma b.v. ()
Clopidogrel teva generics b.v. ()
Clopidogrel teva pharma (previously clopidogrel hcs) ()
Clopidogrel mylan ()
Clopidogrel tad ()
Clopidogrel-tad ()
Clopidogrel teva pharma ()
Clopidogrel dura ()
Clopidogrel-hcs ()
Clopidogrel taw pharma (previously clopidogrel mylan) ()
Clopidogrel-dura ()
Clopidogrel-krka ()
Clopidogrel krka ()
Clopidogrel hcs ()
Clopidogrel krka d.d. (previously zopya) ()
Clopidogrel qualimed ()
P&D ID
PD003042
CAS
113665-84-2
120202-66-6
144077-07-6
135046-48-9
Tags
available
prodrug
drug
Approved by
FDA
EMA
First approval
2011
1997
2009
Drug indication
Recurrent thrombophlebitis
Acute coronary syndrome
Thrombosis
Myocardial infarction
Drug Status
approved
withdrawn
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 29
DESCRIPTION Clopidogrel hydrogen sulfate is an antiplatelet agent to prevent blood clots. Clopidogrel hydrogen sulfate inhibits CYP2B6 and CYP2C19 with IC50s of 18.2 nM and 524 nM, respectively[1]. Clopidogrel hydrogen sulfate is a potent antithrombotic agent that inhibits ADP-induced platelet aggregation[2]£®Clopidogrel hydrogen sulfate also is an orally active P2Y(12) inhibitor[5].
DESCRIPTION Marketed formulations may contain clopidogrel bisulfate (PubChem CID 115366).
DESCRIPTION Clopidogrel is a prodrug converted by liver CYP450 via 2-oxo-clopidogrel to an active metabolite, listed in GtoPdb as . Marketed formulations may contain clopidogrel bisulfate (PubChem CID 115366). (GtoPdb)
DESCRIPTION Clopidogrel is an orally active platelet inhibitor that targets P2Y12 receptor. Clopidogrel is used to inhibit blood clots in coronary artery disease, peripheral vascular disease, and cerebrovascular disease.
PRICE 29
DESCRIPTION Potent ETB antagonist (Tocris Bioactive Compound Library)
DESCRIPTION Clopidogrel hydrogen sulfate is an antiplatelet agent which works by blocking platelets from sticking together and prevents them from forming harmful clots. (Enamine Bioactive Compounds)
DESCRIPTION Clopidogrel hydrogen sulfate ((S)-(+)-Clopidogrel bisulfate) , a selective, high-affinity P2Y12 receptor antagonist, suppressess fibrinogen binding to platelets and platelet adhesion and aggregation. (TargetMol Bioactive Compound Library)
DESCRIPTION Clopidogrel, a thienopyridine derivative, could be used in the prevention and treatment of sorts of arterial circulation disorders caused by platelet aggregation. (BOC Sciences Bioactive Compounds)
DESCRIPTION Clopidogrel (SR-25990C), a P2Y12 receptor antagonist, decreases platelet aggregation. (TargetMol Bioactive Compound Library)
Compound Sets
32
AdooQ Bioactive Compound Library
A10233
BOC Sciences Bioactive Compounds
clopidogrel-cas-113665-84-2-161048
Cayman Chemical Bioactives
21002
10010673
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL1083385
CHEMBL1771
CHEMBL6068333
CHEMBL6068343
CHEMBL6068338
ChEMBL Drugs
CHEMBL1083385
CHEMBL1771
CHEMBL6068333
CHEMBL6068343
CHEMBL6068338
Drug Repurposing Hub
DrugBank
DB00758
DrugBank Approved Drugs
DB00758
DrugCentral
708
DrugCentral Approved Drugs
708
DrugMAP
DMOL54H
DrugMAP Approved Drugs
DMOL54H
Enamine Bioactive Compounds
EBC-07538
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS101424
Guide to Pharmacology
7150
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1771
Mcule NIBR MoA Box Subset
MCULE-4792993119
MedChem Express Bioactive Compound Library
HY-17459
HY-15283
Natural product-based probes and drugs
NCATS Inxight Approved Drugs
A74586SNO7
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Clopidogrel-bisulfate
TargetMol Bioactive Compound Library
T0182L
T0182
The Spectrum Collection
Tocris Bioactive Compound Library
1820
Withdrawn 2.0
EMA8
External IDs
100
Properties
(calculated by RDKit )
Molecular Weight
321.06
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
0
Rotatable Bonds
3
Ring Count
3
Aromatic Ring Count
2
cLogP
3.67
TPSA
29.54
Fraction CSP3
0.31
Chiral centers
1.0
Largest ring
6.0
QED
0.81
Structural alerts
2
aggregator (Aggregator Advisor)
Aggregators
aggregator (ZINC)
Aggregators
Related compounds
Custom attributes
(extracted from source data)
MOA
P2Y receptor antagonist
Antagonist
P2Y12 (P2T) Antagonists
purinergic receptor antagonist
Target
Purinergic receptor P2Y12
Cytochrome P450
P2Y
P2Y12
P2RY12
P2Y Receptor
P2 Receptor
Primary Target
Purinergic (P2Y) Receptors
Member status
member
Indication
myocardial infarction, stroke, peripheral artery disease (PAD), acute coronary syndrome (ACS)
Disease Area
cardiology, neurology/psychiatry
ATC
B01AC04
B01AC06
Therapeutic Indication
Antithrombotic
Therapeutic Class
Cardiovascular
Pathway
GPCR/G protein
Metabolic Enzyme/Protease
Metabolism
Neuroscience
Solubility
10 mM in DMSO
Source data