General
Preferred name
dexamethasone
Synonyms
MK 125 ()
Prednisolone F ()
NSC 34521 ()
Hexadecadrol ()
Dexamethasone50-02-2 ()
NSC 34521, Hexadecadrol, Prednisolone F,MK-125 ()
Dexamethasone (MK-125) ()
Dexamethasone-d4 ()
[3H]dexamethasone ()
Mymethasone ()
OTOMIZE ()
HEXADROL ()
Ozurdex ()
DEXTENZA ()
Neodecadron ()
DEXONE 0.5 ()
ORADEXON ()
Dexamonozon ()
DEXSOL ()
dexamethasone palmitate ()
FLUORMETHYLPREDNISOLONE ()
DEXAMETHASONE INTENSOL ()
DECADRON-75 ()
Loverine ()
Dexamethasone component of maxitrol ()
DEXYCU ()
DEXAMETASONA ()
ISV-305 ()
Dexamethasone component of dexasporin ()
SOFRADEX ()
Dexasite ()
DEXACORTISYL ()
DEXAMETHASONE METASULFOBENZOATE SODIUM ()
OTO-104 ()
Dexa-sine ()
Kortico Injection ()
MARTAPAN ()
Fortecortin ()
Dexacortal ()
Dexamethasone component of tobradex ()
NSC-34521 ()
Dexone ()
TOBRADEX ()
DEXONE 1.5 ()
Dexapos ()
Decadron ()
Isopto-dex ()
DEXYCU KIT ()
MAXITROL ()
DEXONE 4 ()
DEXAFREE ()
AEROSEB-DEX ()
Dexamethasone component of ciprodex ()
DECADERM ()
MAXIDEX ()
GPPE EAR SPY ()
dexamethasone valerate ()
SPERSADEX COMP ()
Dexamethasone component of dexacidin ()
DROPODEX ()
Dexasone ()
DECASPRAY ()
Luxazone ()
Dexamethasone component of tobradex st ()
HEMADY ()
DEXONE 0.75 ()
Dexacortin ()
Dexamethasone ()
DEXA-SINE ()
DEXACORTAL ()
DEXACORTIN ()
DEXAMETHASONE COMPONENT OF CIPRODEX ()
DEXAMETHASONE COMPONENT OF DEXACIDIN ()
DEXAMETHASONE COMPONENT OF DEXASPORIN ()
DEXAMETHASONE COMPONENT OF MAXITROL ()
DEXAMETHASONE COMPONENT OF TOBRADEX ()
DEXAMETHASONE COMPONENT OF TOBRADEX ST ()
DEXAMONOZON ()
DEXAPOS ()
DEXASITE ()
DEXASONE ()
FORTECORTIN ()
ISOPTO-DEX ()
LOVERINE ()
LUXAZONE ()
P&D ID
PD003027
CAS
50-02-2
137098-19-2
23495-06-9
1050677-47-8
2483831-63-4
Tags
available
drug
Approved by
PMDA
EMA
FDA
First approval
1958
Drug indication
Eye inflammation
Rheumatoid arthritis
Drug Status
approved
investigational
vet_approved
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
INDICATION
Injection: for the treatment of endocrine disorders, rheumatic disorders, collagen diseases, dermatologic diseases, allergic statesc, ophthalmic diseases, gastrointestinal diseases, respiratory diseases, hematologic disorders, neoplastic diseases, edematous states, cerebral edema.;
Ophthalmic ointment and solution: for the treatment of steroid responsive inflammatory conditions of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the globe.;
Ophthalmic solution only: for the treatment of steroid responsive inflammatory conditions of the external auditory meatus;
Topic cream: for relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses;
Oral aerosol: for the treatment of bronchial asthma and related corticosteroid responsive bronchospastic states intractable to adequate trial of conventional therapy;
Intranasal aerosol: for the treatment of allergic ot inflammatory nasal conditions, and nasal polyps
Ophthalmic ointment and solution: for the treatment of steroid responsive inflammatory conditions of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the globe.;
Ophthalmic solution only: for the treatment of steroid responsive inflammatory conditions of the external auditory meatus;
Topic cream: for relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses;
Oral aerosol: for the treatment of bronchial asthma and related corticosteroid responsive bronchospastic states intractable to adequate trial of conventional therapy;
Intranasal aerosol: for the treatment of allergic ot inflammatory nasal conditions, and nasal polyps
DESCPRITION
An anti-inflammatory 9-fluoro-glucocorticoid.
PRICE
29
DESCRIPTION
Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist, apoptosis inducer, and common disease inducer in experimental animals, constructing models of muscle atrophy, hypertension, and depression. Dexamethasone can inhibit the production of inflammatory miRNA-155 exosomes in macrophages and significantly reduce the expression of inflammatory factors in neutrophils and monocytes. Dexamethasone also has potential for use in COVID-19 research[1][2][3][4].
DESCRIPTION
Dexamethasone is a glucocorticoid available in various modes of administration that is used for the treatment of various inflammatory conditions, including bronchial asthma, as well as endocrine and rheumatic disorders. Corticosteroids bind to the glucocorticoid receptor, inhibiting pro-inflammatory signals, and promoting anti-inflammatory signals.
(Enamine Bioactive Compounds)
DESCRIPTION
Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist and IL receptor modulator with anti-inflammatory and immunosuppressive properties that induces autophagy and inhibits LPS-induced inflammatory responses in macrophages.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
18
Organisms
2
Compound Sets
33
AdooQ Bioactive Compound Library
Axon Medchem Screening Library
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Enamine Bioactive Compounds
Enamine BioReference Compounds
EUbOPEN Chemogenomics Library
JUMP-Target 1 Compound Set
LSP-MoA library (Laboratory of Systems Pharmacology)
Mcule NIBR MoA Box Subset
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
NURSA ligand set
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
174
Molecular Weight
392.2
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
3
Rotatable Bonds
2
Ring Count
4
Aromatic Ring Count
0
cLogP
1.9
TPSA
94.83
Fraction CSP3
0.73
Chiral centers
8.0
Largest ring
6.0
QED
0.67
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Antibody-drug Conjugate/ADC Related
Autophagy
Endocrinology/Hormones
Immunology/Inflammation
Microbiology/virology
Anti-infection
Vitamin D Related/Nuclear Receptor
MOA
GR agonist
Antiinflammatory Drugs
Glucocorticoid Receptor agonist
Member status
member
Disease Area
endocrinology, rheumatology, allergy, gastroenterology, hematology, neurology/psychiatry, dermatology
Indication
hypercalcemia, rheumatoid arthritis, psoriatic arthritis, osteoarthritis, allergic rhinitis, ulcerative colitis, anemia, multiple sclerosis, enteritis, lupus, dermatitis herpetiformis (DH), nephrotic syndrome, psoriasis
Target
ANXA1, NOS2, NR0B1, NR3C1, NR3C2
Glucocorticoid agonist
ANXA1
ADC Payload
antibiotic
Bacterial
Complement System
Glucocorticoid Receptor
Mitophagy
SARS-CoV
Autophagy,Complement System,COVID-19,Glucocorticoid Receptor,IL Receptor,Mitophagy
ADC Cytotoxin
IL Receptor
Therapeutic Class
Antiinflammatory Agents
Recommended Cell Concentration
100 nM
Source data
