General
Preferred name
DOXORUBICIN HYDROCHLORIDE
Synonyms
Hydroxydaunorubicin hydrochloride ()
Adriamycin ()
Doxorubicin (Adriamycin) HCl ()
NSC 123127 ()
Doxorubicin (HCl) ()
Doxorubicin HCl ()
Doxorubicin (hydrochloride) ()
Hydroxydaunorubicin (hydrochloride) ()
NSC 123127, DOX, Doxorubicin hydrochloride, Hydroxydaunorubicin HCl,Adriamycin HCl ()
Adriamycin Rdf ()
Doxorubicin HCl ()
Doxil ()
Myocet ()
Doxorubicin citric acid salt ()
Rubex ()
Caelyx ()
Liposomal doxorubicin hydrochloride ()
Doxorubicini hydrochloridum ()
Hydroxydaunomycin hydrochloride ()
Adriablastina cs ()
Doxorubicin citrate ()
Doxorubicin liposomal complex of the hydrochloride ()
Doxil (liposomal) ()
Adriamycin Pfs ()
Adriamycin, hydrochloride ()
Doxorubicin hydrochloride (liposomal) ()
P&D ID
PD003015
CAS
25316-40-9
Tags
nuisance
natural product
drug
available
Drug Status
approved
Max Phase
Phase 4
Drug indication
Antineoplastic
First approval
1974
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Antitumor antibiotic agent. Inhibits DNA topoisomerase II (Tocriscreen Plus)
DESCRIPTION Inhibits NGF binding to p75NTR and TrkA (Tocris Bioactive Compound Library)
DESCRIPTION Antitumor antibiotic agent. Inhibits DNA topoisomerase II (Tocriscreen Total)
Cell lines
89
Organisms
3
Compound Sets
15
AdooQ Bioactive Compound Library
A10041
Cayman Chemical Bioactives
15007
ChEMBL Approved Drugs
CHEMBL359744
ChEMBL Drugs
CHEMBL359744
Enamine BioReference Compounds
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL359744
MedChem Express Bioactive Compound Library
HY-15142
NIH Clinical Collections (NCC)
Nuisance compounds in cellular assays
Prestwick Chemical Library
Selleckchem Bioactive Compound Library
Adriamycin
TargetMol Bioactive Compound Library
T1020
Tocris Bioactive Compound Library
2252
Tocriscreen Plus
2252
Tocriscreen Total
External IDs
29
Properties
(calculated by RDKit )
Molecular Weight
579.15
Hydrogen Bond Acceptors
12
Hydrogen Bond Donors
6
Rotatable Bonds
5
Ring Count
5
Aromatic Ring Count
2
cLogP
0.42
TPSA
206.07
Fraction CSP3
0.44
Chiral centers
6.0
Largest ring
6.0
QED
0.23
Structural alerts
6
aggregator (Aggregator Advisor)
Aggregators
historic compounds (Chemical Probes.org)
Obsolete
quinone_A(370)
[!#6&!#1]=[#6]-1-[#6]=,:[#6]-[#6](=[!#6&!#1])-[#6]=,:[#6]-1
PAINS Family A
aggregator (ZINC)
Aggregators
Intercalation
Nuisance compounds in cellular assays
Optical interference
Fluorescence
Nuisance compounds in cellular assays
Related compounds
Custom attributes
(extracted from source data)
Target Type
Enzymes
Pathway
DNA Damage/DNA Repair
Antibody-drug Conjugate/ADC Related
Anti-infection
Apoptosis
Autophagy
Cell Cycle/DNA Damage
Epigenetics
PI3K/Akt/mTOR
Target
Topo II
HCV
ADC Cytotoxin
AMPK
antibiotic
Bacterial
HBV
HIV
Mitophagy
ADC Cytotoxin,AMPK,Antibiotics,Antineoplastic and Immunosuppressive Antibiotics,Apoptosis related,HIV,Mitophagy,Topoisomerase
Primary Target
DNA Topoisomerases
MOA
Topoisomerase
Inhibitor
Source data