General
Preferred name
DOXORUBICIN HYDROCHLORIDE
Synonyms
NSC 123127 ()
Hydroxydaunorubicin hydrochloride ()
Adriamycin HCl ()
DOX hydrochloride ()
Doxorubicin (HCl) ()
Adriamycin ()
Doxorubicin HCl ()
Doxorubicin (hydrochloride) ()
Hydroxydaunorubicin (hydrochloride) ()
ADR ()
NSC 123127, DOX, Doxorubicin hydrochloride, Hydroxydaunorubicin HCl,Adriamycin HCl ()
Doxorubicin (Adriamycin) HCl ()
Doxorubicin HCl ()
Adriablastina cs ()
Myocet liposomal (previously myocet) ()
Doxorubicin hydrochloride (liposomal) ()
Doxorubicin citrate ()
Caelyx pegylated liposomal ()
Doxil (liposomal) ()
Liposomal doxorubicin hydrochloride ()
Celdoxome pegylated liposomal ()
Adriamycin Pfs ()
Adriamycin, hydrochloride ()
Caelyx ()
Zolsketil pegylated liposomal ()
Rubex ()
Doxorubicin hydrochloride component of imx-110 ()
Myocet ()
Doxil ()
Doxorubicin liposomal complex of the hydrochloride ()
Doxorubicini hydrochloridum ()
Adriamycin Rdf ()
Hydroxydaunomycin hydrochloride ()
Doxorubicin citric acid salt ()
P&D ID
PD003015
CAS
25316-40-9
Tags
available
drug
nuisance
Drug Status
approved
Max Phase
4.0
Drug indication
breast carcinoma
First approval
1974
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Doxorubicin hydrochloride (Hydroxydaunorubicin hydrochloride; ADR), a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin hydrochloride is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC50s of 0.8 ¦ÌM and 2.67 ¦ÌM, respectively. Doxorubicin hydrochloride reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin hydrochloride induces apoptosis and autophagy[1][2][3].
PRICE 29
DESCRIPTION Doxorubicin hydrochloride (Adriamycin) belongs to the anthracycline class of antibiotics and is an inhibitor of human DNA topoisomerase I/II (IC50=0.8/2.67 ??M). Doxorubicin hydrochloride exhibits cytotoxicity and antitumor activity. Doxorubicin hydrochloride reduces the phosphorylation of AMPK and its downstream target protein acetyl coenzyme A carboxylase, and induces apoptosis and autophagy.
DESCRIPTION Doxorubicin is a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius. Doxorubicin binds to nucleic acids, presumably by specific intercalation of the planar anthracycline nucleus with the DNA double helix. It is used to treat various cancers and Kaposi's Sarcoma. (Enamine Bioactive Compounds)
DESCRIPTION Antitumor antibiotic agent. Inhibits DNA topoisomerase II (Tocriscreen Plus)
DESCRIPTION Antitumor antibiotic agent. Inhibits DNA topoisomerase II (Tocriscreen Total)
DESCRIPTION Doxorubicin hydrochloride (Adriamycin) belongs to the anthracycline class of antibiotics and is an inhibitor of human DNA topoisomerase I/II (IC50=0.8/2.67 μM). Doxorubicin hydrochloride exhibits cytotoxicity and antitumor activity. Doxorubicin hydrochloride reduces the phosphorylation of AMPK and its downstream target protein acetyl coenzyme A carboxylase, and induces apoptosis and autophagy. (TargetMol Bioactive Compound Library)
DESCRIPTION Inhibits NGF binding to p75NTR and TrkA (Tocris Bioactive Compound Library)
Cell lines
102
Organisms
3
Compound Sets
17
AdooQ Bioactive Compound Library
A10041
Cayman Chemical Bioactives
15007
ChEMBL Approved Drugs
CHEMBL359744
ChEMBL Drugs
CHEMBL359744
CZ-OPENSCREEN Bioactive Library
Enamine Bioactive Compounds
EBC-11150
Enamine BioReference Compounds
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL359744
MedChem Express Bioactive Compound Library
HY-15142
NIH Clinical Collections (NCC)
Nuisance compounds in cellular assays
Prestwick Chemical Library
Selleckchem Bioactive Compound Library
Adriamycin
TargetMol Bioactive Compound Library
T1020
Tocris Bioactive Compound Library
2252
Tocriscreen Plus
2252
Tocriscreen Total
External IDs
30
Properties
(calculated by RDKit )
Molecular Weight
579.15
Hydrogen Bond Acceptors
12
Hydrogen Bond Donors
6
Rotatable Bonds
5
Ring Count
5
Aromatic Ring Count
2
cLogP
0.42
TPSA
206.07
Fraction CSP3
0.44
Chiral centers
6.0
Largest ring
6.0
QED
0.23
Structural alerts
5
aggregator (Aggregator Advisor)
Aggregators
historic compounds (Chemical Probes.org)
Obsolete
aggregator (ZINC)
Aggregators
Intercalation
Nuisance compounds
Optical interference
Fluorescence
Nuisance compounds
Related compounds
Custom attributes
(extracted from source data)
Target Type
Enzymes
Pathway
Antibody-drug Conjugate/ADC Related
Apoptosis
Autophagy
Chromatin/Epigenetic
DNA Damage/DNA Repair
Microbiology/virology
PI3K/Akt/mTOR signaling
Proteases/Proteasome
Anti-infection
Cell Cycle/DNA Damage
Epigenetics
PI3K/Akt/mTOR
Primary Target
DNA Topoisomerases
MOA
Topoisomerase
Inhibitor
Target
HCV
ADC Payload
AMPK
antibiotic
Bacterial
HBV
HIV
Mitophagy
ADC Cytotoxin,AMPK,Antibiotics,Antineoplastic and Immunosuppressive Antibiotics,Apoptosis related,HIV,Mitophagy,Topoisomerase
ADC Cytotoxin
Topo II
Source data