General
Preferred name
ethinylestradiol
Synonyms
ETHINYL ESTRADIOL ()
17¦Á-Ethynylestradiol ()
17α-Ethynylestradiol ()
Marvelon-ethinylestradiol ()
ETHYNYLESTRADIOL57-63-6 ()
Ethynyl Estradiol ()
Ethinyl estradiol component of isibloom ()
Ethinyl estradiol component of nordette ()
Ethinyl estradiol component of lessina ()
Ethinyl estradiol component of altavera ()
Ethinyl estradiol component of tyblume ()
Ethinyl estradiol component of elifemme ()
17ALPHA-ETHINYLESTRADIOL ()
Ethinyl estradiol component of nuvaring ()
Ovulen-28 ()
Ethinyl estradiol component of bekyree ()
Ethinyl estradiol component of enskyce ()
Ovulen-21 ()
Ethinyl estradiol component of zovia ()
Ethinyl estradiol component of femcon fe ()
Ethinyl estradiol component of levlite ()
Ethinyl estradiol component of marlissa ()
Ethinyl estradiol component of femhrt ()
Ethinyl estradiol component of kelnor ()
Ethinyl estradiol component of lo loestrin fe ()
Ethinyl estradiol component of lybrel ()
Ethinyl estradiol component of minastrin 24 fe ()
Ethinyl estradiol component of sprintec ()
Ethinyl estradiol component of tri-legest fe ()
ETINILESTRADIOL ()
Ethinyl estradiol component of enpresse ()
Ethinyl estradiol component of estrostep fe ()
Ethinyl estradiol component of balcoltra ()
Follicoral ()
Ethinyl estradiol component of viorele ()
Ethynylestradiol ()
Ethinyl estradiol component of seasonale ()
Ethinyl estradiol component of seasonique ()
Ethinyl estradiol component of levonest ()
Ethinyl estradiol component of ortho tri-cyclen ()
Ethinyl estradiol component of yasmin ()
Ethinyl estradiol component of alesse ()
Ethinyl estradiol component of kurvelo ()
LYNORAL ()
Ethinyl estradiol component of femlyv ()
FEMINONE ()
Ethinyl estradiol component of aranelle ()
Ethinyl estradiol component of pimtrea ()
Ethinyl estradiol component of safyral ()
Enovid ()
Ethinyl estradiol component of taytulla ()
Ethinyl estradiol component of mircette ()
Ethinyl estradiol component of cyclessa ()
Ethinyl estradiol component of volnea ()
Ginestrene ()
Ethinyl estradiol component of previfem ()
Ethinyl estradiol component of twirla ()
Ethinyl estradiol component of aviane ()
Ethinyl estradiol component of cryselle ()
Ethinyl estradiol component of ortho-cept ()
Ethinyl estradiol component of portia ()
Ethinyl estradiol component of desogen ()
Ethinyl estradiol component of loseasonique ()
Ethinyl estradiol component of kariva ()
Ethinyl estradiol component of velivet ()
Ethinyl estradiol component of brevicon ()
ESTINYL ()
Ethinyl estradiol component of setlakin ()
Ethinyl estradiol component of orsythia ()
17-ETHINYLESTRADIOL ()
Ethinyl estradiol component of vienva ()
Ovulen ()
Ethinyl estradiol component of yaz ()
Ethinyl estradiol component of quartette ()
Ethinyl estradiol component of norquest fe ()
Ethinyl estradiol component of vyfemla ()
Ethinyl estradiol component of introvale ()
Enovid-E ()
ETHINYLESTRADIOLUM ()
Ethinylestradiol ()
Ethinyl estradiol component of levora ()
Ethinyl estradiol component of tri-sprintec ()
Ethinyl estradiol component of xulane ()
Ethinyl estradiol component of quasense ()
Etinestryl ()
Ethinyl estradiol component of beyaz ()
Ethinyl estradiol component of tri-previfem ()
Ethinyl estradiol component of triphasil ()
Ethinyl estradiol component of lo minastrin fe ()
Ethinyl estradiol component of trivora ()
Ethinyl estradiol component of annovera ()
Ethinyl estradiol component of ovral ()
Ethinyl estradiol component of preven ()
NSC-10973 ()
Ethinyl estradiol component of tri lo sprintec ()
Ethinyl estradiol component of norinyl ()
ETHINYL ESTRADIOL COMPONENT OF ALESSE ()
ETHINYL ESTRADIOL COMPONENT OF ALTAVERA ()
ETHINYL ESTRADIOL COMPONENT OF ANNOVERA ()
ETHINYL ESTRADIOL COMPONENT OF ARANELLE ()
ETHINYL ESTRADIOL COMPONENT OF AVIANE ()
ETHINYL ESTRADIOL COMPONENT OF BALCOLTRA ()
ETHINYL ESTRADIOL COMPONENT OF BEKYREE ()
ETHINYL ESTRADIOL COMPONENT OF BEYAZ ()
ETHINYL ESTRADIOL COMPONENT OF BREVICON ()
ETHINYL ESTRADIOL COMPONENT OF CRYSELLE ()
ETHINYL ESTRADIOL COMPONENT OF CYCLESSA ()
ETHINYL ESTRADIOL COMPONENT OF DESOGEN ()
ETHINYL ESTRADIOL COMPONENT OF ELIFEMME ()
ETHINYL ESTRADIOL COMPONENT OF ENPRESSE ()
ETHINYL ESTRADIOL COMPONENT OF ENSKYCE ()
ETHINYL ESTRADIOL COMPONENT OF ESTROSTEP FE ()
ETHINYL ESTRADIOL COMPONENT OF FEMCON FE ()
ETHINYL ESTRADIOL COMPONENT OF FEMHRT ()
ETHINYL ESTRADIOL COMPONENT OF FEMLYV ()
ETHINYL ESTRADIOL COMPONENT OF INTROVALE ()
ETHINYL ESTRADIOL COMPONENT OF ISIBLOOM ()
ETHINYL ESTRADIOL COMPONENT OF KARIVA ()
ETHINYL ESTRADIOL COMPONENT OF KELNOR ()
ETHINYL ESTRADIOL COMPONENT OF KURVELO ()
ETHINYL ESTRADIOL COMPONENT OF LESSINA ()
ETHINYL ESTRADIOL COMPONENT OF LEVLITE ()
ETHINYL ESTRADIOL COMPONENT OF LEVONEST ()
ETHINYL ESTRADIOL COMPONENT OF LEVORA ()
ETHINYL ESTRADIOL COMPONENT OF LO LOESTRIN FE ()
ETHINYL ESTRADIOL COMPONENT OF LO MINASTRIN FE ()
ETHINYL ESTRADIOL COMPONENT OF LOSEASONIQUE ()
ETHINYL ESTRADIOL COMPONENT OF LYBREL ()
ETHINYL ESTRADIOL COMPONENT OF MARLISSA ()
ETHINYL ESTRADIOL COMPONENT OF MINASTRIN 24 FE ()
ETHINYL ESTRADIOL COMPONENT OF MIRCETTE ()
ETHINYL ESTRADIOL COMPONENT OF NORDETTE ()
ETHINYL ESTRADIOL COMPONENT OF NORINYL ()
ETHINYL ESTRADIOL COMPONENT OF NORQUEST FE ()
ETHINYL ESTRADIOL COMPONENT OF NUVARING ()
ETHINYL ESTRADIOL COMPONENT OF ORSYTHIA ()
ETHINYL ESTRADIOL COMPONENT OF ORTHO TRI-CYCLEN ()
ETHINYL ESTRADIOL COMPONENT OF ORTHO-CEPT ()
ETHINYL ESTRADIOL COMPONENT OF OVRAL ()
ETHINYL ESTRADIOL COMPONENT OF PIMTREA ()
ETHINYL ESTRADIOL COMPONENT OF PORTIA ()
ETHINYL ESTRADIOL COMPONENT OF PREVEN ()
ETHINYL ESTRADIOL COMPONENT OF PREVIFEM ()
ETHINYL ESTRADIOL COMPONENT OF QUARTETTE ()
ETHINYL ESTRADIOL COMPONENT OF QUASENSE ()
ETHINYL ESTRADIOL COMPONENT OF SAFYRAL ()
ETHINYL ESTRADIOL COMPONENT OF SEASONALE ()
ETHINYL ESTRADIOL COMPONENT OF SEASONIQUE ()
ETHINYL ESTRADIOL COMPONENT OF SETLAKIN ()
ETHINYL ESTRADIOL COMPONENT OF SPRINTEC ()
ETHINYL ESTRADIOL COMPONENT OF TAYTULLA ()
ETHINYL ESTRADIOL COMPONENT OF TRI LO SPRINTEC ()
ETHINYL ESTRADIOL COMPONENT OF TRI-LEGEST FE ()
ETHINYL ESTRADIOL COMPONENT OF TRI-PREVIFEM ()
ETHINYL ESTRADIOL COMPONENT OF TRI-SPRINTEC ()
ETHINYL ESTRADIOL COMPONENT OF TRIPHASIL ()
ETHINYL ESTRADIOL COMPONENT OF TRIVORA ()
ETHINYL ESTRADIOL COMPONENT OF TWIRLA ()
ETHINYL ESTRADIOL COMPONENT OF TYBLUME ()
ETHINYL ESTRADIOL COMPONENT OF VELIVET ()
ETHINYL ESTRADIOL COMPONENT OF VIENVA ()
ETHINYL ESTRADIOL COMPONENT OF VIORELE ()
ETHINYL ESTRADIOL COMPONENT OF VOLNEA ()
ETHINYL ESTRADIOL COMPONENT OF VYFEMLA ()
ETHINYL ESTRADIOL COMPONENT OF XULANE ()
ETHINYL ESTRADIOL COMPONENT OF YASMIN ()
ETHINYL ESTRADIOL COMPONENT OF YAZ ()
ETHINYL ESTRADIOL COMPONENT OF ZOVIA ()
P&D ID
PD003002
CAS
406932-93-2
1050678-65-3
57-63-6
Tags
available
probe
drug
Approved by
PMDA
FDA
First approval
1982
1943
Drug indication
Neoplasm
Female hypogonadism
Drug Status
approved
withdrawn
Max Phase
4.0
Probe info
Probe type
calculated probe
Probe sources
Probe Miner (suitable probes)
Probe targets
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Ethinylestradiol is contained in a large number of combined oral contraceptive formulations and HRT medications. Use of ethinylestradiol, unapposed by a progestin, increases the risk of endometrial cancer. (GtoPdb)
DESCRIPTION Ethinylestradiol is an orally active steroidal estrogen. Ethinylestradiol is widely used in research on menopausal symptoms, gynecological conditions, and certain hormone-sensitive cancers[1].
PRICE 29
DESCRIPTION Ethinylestradiol is a synthetic estrogen that decreases luteinizing hormone to decrease endometrial vascularization, and decreases gonadotrophic hormone to prevent ovulation. Ethinylestradiol is combined with other drugs for use as a contraceptive, premenstrual dysphoric disorder, moderate acne, moderate to severe vasomotor symptoms of menopause, prevention of postmenopausal osteoporosis. (Enamine Bioactive Compounds)
DESCRIPTION Ethynyl estradiol is a semisynthetic alkylated ESTRADIOL with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orally, and is often used as the estrogenic component in ORAL CONTRACEPTIVES. (TargetMol Bioactive Compound Library)
Cell lines
2
Organisms
0
Compound Sets
35
Cayman Chemical Bioactives
10006486
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL691
ChEMBL Drugs
CHEMBL691
Concise Guide to Pharmacology 2017/18
7071
Concise Guide to Pharmacology 2019/20
7071
Concise Guide to Pharmacology 2021/22
7071
Concise Guide to Pharmacology 2023/24
7071
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB00977
DrugBank Approved Drugs
DB00977
DrugCentral
1082
DrugCentral Approved Drugs
1082
DrugMAP
DMODJ40
DrugMAP Approved Drugs
DMODJ40
Enamine Bioactive Compounds
EBC-11049
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS101551
EUbOPEN Chemogenomics Library
EUB0000580
Guide to Pharmacology
7071
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL691
Mcule NIBR MoA Box Subset
MCULE-5991854877
MedChem Express Bioactive Compound Library
HY-B0216
Natural product-based probes and drugs
NCATS Inxight Approved Drugs
423D2T571U
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
Probe Miner (suitable probes)
P03372/1323684
ReFrame library
Selleckchem Bioactive Compound Library
Ethinyl-Estradiol
TargetMol Bioactive Compound Library
T1424
Withdrawn 2.0
w200
External IDs
61
Properties
(calculated by RDKit )
Molecular Weight
296.18
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
0
Ring Count
4
Aromatic Ring Count
1
cLogP
3.61
TPSA
40.46
Fraction CSP3
0.6
Chiral centers
5.0
Largest ring
6.0
QED
0.72
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
Estrogen receptor agonist
Estrogen Receptor (ER) Agonists
estrogen receptor agonist, estrogenic hormone
Target
Estrogen receptor alpha
Endogenous Metabolite
ER
Estrogen Receptor/ERR
ESR1, ESR2, NR1I2
Estrogen/progestogen Receptor
Member status
member
Indication
contraceptive
ATC
G03CA01
L02AA03
Toxicity type
multiple
Biosynthetic Origin
Terpenoid (Steroid)
Therapeutic Indication
Contraception
Therapeutic Class
Hormone Therapy
Estrogens
Pathway
Endocrinology/Hormones
Metabolism
Metabolic Enzyme/Protease
Vitamin D Related/Nuclear Receptor
Recommended Cell Concentration
1 uM
Source data