General
Preferred name
fluvastatin
Synonyms
FLUVASTATIN SODIUM ()
Fluvastatin (D6 sodium) ()
XU 62320 D6 sodium ()
XU 62320 ()
Fluvastatin sodium salt ()
XU-62-320 ()
XU 62320 sodium ()
XU 62-320 (D6) ()
fluvastatin93957-54-1 ()
(3R,5S)-Fluvastatin (sodium) ()
Fluvastatin (sodium) ()
(3R,5S)-XU 62-320 ()
XU 62-320 (free acid) ()
XU 62-320 ()
Vastin,XU-62-320 ()
Fluvastatin (XU-62-320) Sodium ()
Lescol ()
Fluvastatin-d6 (sodium salt) ()
P&D ID
PD002988
CAS
94061-80-0
93957-55-2
93957-54-1
Tags
available
drug
Drug indication
Hypercholesterolaemia
Drug Status
approved
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 29
DESCRIPTION Fluvastatin sodium (XU 62320) is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM. Fluvastatin sodium protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway[1][2][3].
DESCRIPTION (3R,5S)-Fluvastatin ((3R,5S)-XU 62-320) sodium is the 3R,5S-isomer Fluvastatin. Fluvastatin (XU 62-320 free acid) is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway[1][2][3].
DESCRIPTION Fluvastatin is a member of the cholesterol-lowering statin family of drugs. The approved drug is a racemic mixture of a 3R, 5S isomer and a 3S, 5R isomer, and this is supported by the INN document which also indicates a racemate. The 3R, 5S isomer (shown here, and in the PubChem link below) is more pharmacologically active . The other isomer is represented by CID 1548972. Representations of the stereochemistry of fluvastatin shown on the resources linked to below may vary from the structure shown here. The majority of the references we cite for our biological activity data do not specify whether the racemate or a specific stereoisomer were used in their experiments. (GtoPdb)
DESCRIPTION Fluvastatin (XU 62-320 free acid) is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway[1][2][3].
DESCRIPTION Fluvastatin is an HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke. (Enamine Bioactive Compounds)
DESCRIPTION Fluvastatin sodium (Fluvastatin sodium salt), a competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase (HMGCR), is a commonly used cholesterol lowering agent. (TargetMol Bioactive Compound Library)
DESCRIPTION Fluvastatin is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase (HMGCR) with IC50 of 8 nM. It belongs to a class of the statin drug and is structurally distinct from the fungal derivatives of this therapeutic class. It binds of the substrate HMG-CoA with Ki value of 0.3 nM but not with respect to binding of NADPH. It is marketed under the trade name Lescol® and is used to treat hypercholesterolemia and to prevent cardiovascular disease. It induces G2/M phase arrest and has antilipemic effect. (BOC Sciences Bioactive Compounds)
Compound Sets
21
AdooQ Bioactive Compound Library
A10403
BOC Sciences Bioactive Compounds
fluvastatin-cas-93957-54-1-item-79856
Cayman Chemical Bioactives
25433
Concise Guide to Pharmacology 2017/18
2951
Concise Guide to Pharmacology 2019/20
2951
Concise Guide to Pharmacology 2021/22
2951
Concise Guide to Pharmacology 2023/24
2951
Drug Repurposing Hub
DrugMAP
DM4MDJY
DrugMAP Approved Drugs
DM4MDJY
Enamine Bioactive Compounds
EBC-13130
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS100776
Guide to Pharmacology
2951
MedChem Express Bioactive Compound Library
HY-14664A
HY-14664F
HY-14664
NIH Clinical Collections (NCC)
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
Fluvastatin-Sodium(Lescol)
TargetMol Bioactive Compound Library
T1487
The Spectrum Collection
External IDs
45
Properties
(calculated by RDKit )
Molecular Weight
411.18
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
3
Rotatable Bonds
8
Ring Count
3
Aromatic Ring Count
3
cLogP
4.63
TPSA
82.69
Fraction CSP3
0.29
Chiral centers
2.0
Largest ring
6.0
QED
0.5
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Autophagy
HMG-CoA Reductase (HMGCR)
HMGCR
Ferroptosis
HMG-CoA Reductase
Pathway
Metabolic Enzyme/Protease
Apoptosis
Metabolism
MOA
HMG-CoA Reductase inhibitor
HMGCR inhibitor
Indication
hypercholesterolemia, congenital heart defects
Disease Area
endocrinology, cardiology
Therapeutic Class
Anticholesteremic Agents
Solubility
10 mM in DMSO
Source data