General
Preferred name
hydrocortisone succinate
Synonyms
HYDROCORTISONE HEMISUCCINATE ()
Hydrocortisone hemisuccinate (hydrate) ()
Hydrocortisone hemisuccinate (sodium) ()
Hydrocortisone 21-hemisuccinate ()
Hydrocortisone 21-hemisuccinate (hydrate) ()
Hydrocortisone 21-hemisuccinate (sodium) ()
A-hydrocort, Hydrocortisone 21-hemisuccinate ()
Hydrocortisone 21-hemisuccinate sodium salt ()
HYDROCORTISONE SODIUM SUCCINATE ()
HYDROCORTISONE HEMISUCCINATE ANHYDROUS ()
Hydrocortisone 21-hemisuccinate (sodium salt) ()
Hydrocortisone 21-sodium succinate ()
Solu-Cortef ()
Hcss ()
Cortisol 21-(sodium succinate) ()
A-hydrocort ()
NSC-9152 ()
Hydrocortisoni natrii succinas ()
Oristar hcshs ()
NSC-7576 ()
Cortisol 21-(hydrogen succinate) ()
Hydrocortisone Succinate ()
NSC-757049 ()
Hydrocortisone hydrogen succinate ()
Cortisol succinate ()
Hydroxycortisone succinate ()
P&D ID
PD002973
CAS
2203-97-6
83784-20-7
125-04-2
Tags
available
prodrug
drug
drug candidate
Approved by
FDA
First approval
1955
Drug Status
approved
Max Phase
4.0
Drug indication
acute lymphoblastic leukemia
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Hydrocortisone hemisuccinate sodium is an orally active physiological glucocorticoid. Hydrocortisone hemisuccinate sodium inhibits proinflammatory cytokine activity, with IC50s of 6.7 and 21.4 ¦ÌM for IL-6 and IL-3, respectively. Hydrocortisone hemisuccinate sodium can be used for the research of ulcerative colitis (UC)[1].
DESCRIPTION Hydrocortisone hemisuccinate (Hydrocortisone 21-hemisuccinate), a glucocorticoid, is an orally active steroidal anti-inflammatory agent (SAID) with anti-inflammatory and immunomodulatory activities. Hydrocortisone hemisuccinate inhibits the bioactivity of IL-6 and IL-3 with IC50 values of 6.7 and 21.4 ¦ÌM, respectively. Hydrocortisone hemisuccinate can be used in the study of ulcerative colitis (UC) and recurrent oral ulcers[1][2][3].
DESCRIPTION Hydrocortisone hemisuccinate hydrate (Hydrocortisone 21-hemisuccinate hydrate), a glucocorticoid, is an orally active steroidal anti-inflammatory agent (SAID) with anti-inflammatory and immunomodulatory activities. Hydrocortisone hemisuccinate hydrate inhibits the bioactivity of IL-6 and IL-3 with IC50 values of 6.7 and 21.4 ¦ÌM, respectively. Hydrocortisone hemisuccinate hydrate can be used in the study of ulcerative colitis (UC) and recurrent oral ulcers[1][2][3].
Cell lines
1
Organisms
1
Compound Sets
13
Cayman Chemical Bioactives
18226
ChEMBL Approved Drugs
CHEMBL1200495
CHEMBL977
ChEMBL Drugs
CHEMBL1200495
CHEMBL977
CHEMBL3989663
Drug Repurposing Hub
DrugBank
DB14545
DrugBank Approved Drugs
DB14545
DrugCentral
4456
DrugCentral Approved Drugs
4456
MedChem Express Bioactive Compound Library
HY-B1402B
HY-B1402
HY-B1402A
NIH Clinical Collections (NCC)
NPC Screening Collection
Other bioactive compounds
Selleckchem Bioactive Compound Library
hydrocortisone-sodium-succinate
hydrocortisone-hemisuccinate
External IDs
65
Properties
(calculated by RDKit )
Molecular Weight
462.23
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
3
Rotatable Bonds
6
Ring Count
4
Aromatic Ring Count
0
cLogP
2.2
TPSA
138.2
Fraction CSP3
0.76
Chiral centers
7.0
Largest ring
6.0
QED
0.51
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Interleukin Related
Glucocorticoid Receptor
Interleukins
Glucocorticoid Receptor,Interleukins
Pathway
Immunology/Inflammation
Vitamin D Related/Nuclear Receptor
Source data