General
Preferred name
ISOQUERCETIN
Synonyms
Contigoside B ()
Isoquercitrin ()
Quercetin 3-glucoside ()
Hirsutrin, 3-Glucosylquercetin, Quercetin 3-o-glucopyranoside ()
Quercetol 3-monoglucoside ()
Quercetin 3-o-glucoside ()
Ronacare isoquercetin ()
Quercetin 3-o-glucopyranoside ()
NSC-115918 ()
Quercetin 3.beta.-glucoside ()
Isotrifoliin ()
Isoquercetin, (-)- ()
Isotrifolin ()
FEMA NO. 4225 ()
Hirsutrin ()
Quercetin-3-o-glucoside ()
Quercetin 3-d-glucoside ()
Quercetin glucoside ()
3-Glucosylquercetin ()
NSC-407304 ()
Isoquercitroside ()
Quercetin-3-glucose ()
Glucosyl-3-quercetin ()
P&D ID
PD002964
CAS
482-35-9
Tags
available
drug candidate
nuisance
Drug indication
Renal cell carcinoma
Thrombosis
Drug Status
investigational
Max Phase
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Isoquercetin (Quercetin 3-glucoside) is a naturally occurring polyphenol that has antioxidant, anti-proliferative, and anti-inflammatory properties. Isoquercetin alleviates ethanol-induced hepatotoxicity, oxidative stress, and inflammatory responses via the Nrf2/ARE antioxidant signaling pathway[1]. Isoquercetin regulates the expression of nitric oxide synthase 2 (NO2) via modulating the nuclear factor-¦ÊB (NF-¦ÊB) transcription regulation system. Isoquercetin has high bioavailability and low toxicity, is a promising candidate agent to prevent birth defects in diabetic pregnancies[2].
PRICE
56
DESCRIPTION
1. Isoquercetin (3-Glucosylquercetin) is a potential stimulator of bone mineralization used for prophylaxis of osteoporotic disorders. 2. Isoquercetin may be as a potential therapeutic agent against neurodegeneration in Parkinson's disease. 3. Isoquercetin is an inhibitor of Wnt/??-catenin and may be as a potential novel anti-tumoral agent, such as against human pancreati,liver cancer related to opioid receptors and to the activation of the mitogen-activated protein kinase (MAPK) signalling pathway. .
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
3
Organisms
1
Compound Sets
11
Cayman Chemical Bioactives
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugMAP
MedChem Express Bioactive Compound Library
NIH Clinical Collections (NCC)
Nuisance compounds in cellular assays
ReFrame library
Selleckchem Bioactive Compound Library
ZINC Tool Compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
52
Molecular Weight
464.1
Hydrogen Bond Acceptors
12
Hydrogen Bond Donors
8
Rotatable Bonds
4
Ring Count
4
Aromatic Ring Count
3
cLogP
-0.54
TPSA
210.51
Fraction CSP3
0.29
Chiral centers
5.0
Largest ring
6.0
QED
0.23
Structural alerts
1
Nonspecific/NOS
Flavonoid
Nuisance compounds
Related compounds
Custom attributes
(extracted from source data)
MOA
Wnt/beta-catenin
Antioxidant
Target
NF-¦ÊB
Wnt/??catenin
NF-κB
NO Synthase
Pathway
Immunology/Inflammation
Source data
