General
Preferred name
PAZUFLOXACIN
Synonyms
PAZUFLOXACIN MESYLATE ()
T3761 ()
Pazucross ()
Pazufloxacin mesilate ()
T-3762 ()
Pazufloxacin methanesulfonate ()
Pazufloxacin (mesylate) ()
T-3762, Pazucross ()
Pazufloxacine ()
T-3761 ()
Pazufloxacino ()
P&D ID
PD002924
CAS
163680-77-1
127045-41-4
Tags
available
drug
Drug indication
Otitis media
Conjunctivitis
Bacterial conjunctivitis
Drug Status
approved
investigational
Max Phase
3.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 29
DESCRIPTION Pazufloxacin (T-3761) mesylate is a fluoroquinolone antibiotic.;Target: Antibacterial;Pazufloxacin (T-3761), a new quinolone derivative, showed broad and potent antibacterial activity. T-3761 showed good efficacy in mice against systemic, pulmonary, and urinary tract infections with gram-positive and gram-negative bacteria, including quinolone-resistant Serratia marcescens and Pseudomonas aeruginosa. The in vivo activity of T-3761 was comparable to or greater than those of ofloxacin, ciprofloxacin, norfloxacin, and tosufloxacin against most infection models in mice. The activities of T-3761 were lower than those of tosufloxacin against gram-positive bacterial systemic and pulmonary infections in mice but not against infections with methicillin-resistant Staphylococcus aureus [1]. T-3761 had a broad spectrum of activity and had potent activity against gram-positive and -negative bacteria. The MICs of T-3761 against 90% of the methicillin-susceptible Staphylococcus aureus, methicillin-susceptible and -resistant Staphylococcus epidermidis, and Clostridium spp. tested were 0.39 to 6.25 micrograms/ml. The MBCs of T-3761 were either equal to or twofold greater than the MICs. The 50% inhibitory concentrations of T-3761 for DNA gyrases isolated from E. coli and P. aeruginosa were 0.88 and 1.9 micrograms/ml, respectively [2].
DESCRIPTION Pazufloxacin is an orally bioavailable fluoroquinolone compound with broad-spectrum antibacterial activity . The drug is administered clinically as the mesylate salt (PubChem CID 6918232, T-3762). (GtoPdb)
DESCRIPTION Pazufloxacin Mesylate (T-3762) is a fluoroquinolone antibiotic. (TargetMol Bioactive Compound Library)
DESCRIPTION Pazufloxacin (T-3761), a new quinolone derivative, showed broad and potent antibacterial activity. T-3761 showed good efficacy in mice against systemic, pulmonary, and urinary tract infections with gram-positive and gram-negative bacteria, including quinolone-resistant Serratia marcescens and Pseudomonas aeruginosa. The in vivo activity of T-3761 was comparable to or greater than those of ofloxacin, ciprofloxacin, norfloxacin, and tosufloxacin against most infection models in mice. The activities of T-3761 were lower than those of tosufloxacin against gram-positive bacterial systemic and pulmonary infections in mice but not against infections with methicillin-resistant Staphylococcus aureus. T-3761 had a broad spectrum of activity and had potent activity against gram-positive and -negative bacteria. The MICs of T-3761 against 90% of the methicillin-susceptible Staphylococcus aureus, methicillin-susceptible and -resistant Staphylococcus epidermidis, and Clostridium spp. tested were 0.39 to 6.25 micrograms/ml. The MBCs of T-3761 were either equal to or twofold greater than the MICs. The 50% inhibitory concentrations of T-3761 for DNA gyrases isolated from E. coli and P. aeruginosa were 0.88 and 1.9 micrograms/ml, respectively. (BOC Sciences Bioactive Compounds)
Cell lines
0
Organisms
2
Compound Sets
17
BOC Sciences Bioactive Compounds
pazufloxacin-cas-127045-41-4-item-84-56631
Cayman Chemical Bioactives
29249
ChEMBL Drugs
CHEMBL240163
Drug Repurposing Hub
DrugBank
DB11774
DrugCentral
2070
DrugCentral Approved Drugs
2070
DrugMAP
DMHXTAQ
DMP3G0W
Enamine BioReference Compounds
Guide to Pharmacology
12410
MedChem Express Bioactive Compound Library
HY-B0724A
NIH Clinical Collections (NCC)
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
pazufloxacin-mesylate
TargetMol Bioactive Compound Library
T1620
The Spectrum Collection
External IDs
47
Properties
(calculated by RDKit )
Molecular Weight
318.1
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
2
Rotatable Bonds
2
Ring Count
4
Aromatic Ring Count
2
cLogP
1.74
TPSA
94.55
Fraction CSP3
0.38
Chiral centers
1.0
Largest ring
6.0
QED
0.88
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Bacterial
antibiotic
Topo II
DNA/RNA Synthesis
Pathway
Anti-infection
DNA Damage/DNA Repair
Microbiology/virology
Cell Cycle/DNA Damage
Indication
pneumonia, peritonitis, bacterial septicemia
MOA
Topoisomerase inhibitor
Source data