General
Preferred name
PHENELZINE
Synonyms
PHENELZINE SULFATE ()
Phenelzine Dihydrochloride ()
Phenelzine (sulfate) ()
Phenelzine acid sulfate ()
Nardil ()
NSC-170957 ()
Phenelzine sulphate ()
Fenelzina ()
Phenelzine-d5 (sulfate) ()
(2-phenylethyl)hydrazine dihydrochloride ()
P&D ID
PD002918
CAS
156-51-4
51-71-8
16904-30-6
14847-47-3
1219798-40-9
Tags
available
drug
Approved by
FDA
First approval
1961
Drug indication
Skin imperfections
prostate adenocarcinoma
Depression
Major depressive disorder
Drug Status
approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 29
DESCRIPTION Phenelzine is a monoamine oxidase inhibitor (MAOI). (GtoPdb)
INDICATION Phenelzine is indicated for the treatment of nonendogenous, neurotic or atypical depression for patients that do not tolerate other forms of therapy.[L1356] ; ; Atypical depression has a high prevalence rate, starts in early life, tends to last longer, is more likely to occur in people with bipolar disorder, has a high comorbidity with anxiety disorder and carries more risk of suicidal behavior. It is important to specify the atypical feature to predict the clinical course of depression and hence generate the best treatment and service. The featuring symptoms of the atypical feature include mood reactivity, two or more of this symptoms: 1) increased appetite, 2) increased sleep, 3) leaden paralysis and 4) interpersonal rejection sensitivity and should not have melancholic or catatonic features of depression.[A31917]; ; Neurotic depression is a depression of an emotionally unstable person. It is a secondary condition to major personality disorder, neuroses and drug use disorders. Likewise, a primary depression with a family history of depression spectrum disease would fit in this category.[A31922]; ; A nonendogenous depression is characterized by a disturbance in mood and general outlook. The physical symptoms tend to be less severe and it often occurs in response to stressful life events that keep occurring over a large period of time generating a continuous stress in the daily living.[A31924]
PRICE 29
DESCRIPTION (2-phenylethyl)hydrazine dihydrochloride is used in the synthesis of various drugs, in the production of certain types of plastics, and in the manufacture of certain types of dyes.
DESCRIPTION Non-selective MAO-A/B inhibitor (LOPAC library)
DESCRIPTION Phenelzine sulfate is a non-selective, irreversible monoamine oxidase inhibitor (MAOI) with antidepressant and anxiolytic properties. (TargetMol Bioactive Compound Library)
DESCRIPTION Phenelzine, with the formula ?-phenylethylhydrazine, is a monoamine oxidase inhibiting antidepressant that is effective in the treatment of panic disorder and social anxiety disorder. Phenelzine is indicated for the treatment of nonendogenous, neurotic or atypical depression for patients that do not tolerate other forms of therapy. (Enamine Bioactive Compounds)
Cell lines
0
Organisms
1
Compound Sets
33
Cayman Chemical Bioactives
23956
29645
ChEMBL Approved Drugs
CHEMBL1200895
CHEMBL1089
ChEMBL Drugs
CHEMBL1200895
CHEMBL1089
Concise Guide to Pharmacology 2017/18
7266
Concise Guide to Pharmacology 2019/20
7266
Concise Guide to Pharmacology 2021/22
7266
Concise Guide to Pharmacology 2023/24
7266
Drug Repurposing Hub
DrugBank
DB00780
DrugBank Approved Drugs
DB00780
DrugCentral
2123
DrugCentral Approved Drugs
2123
DrugMAP
DMHIDUE
DrugMAP Approved Drugs
DMHIDUE
DrugMatrix
Enamine Bioactive Compounds
EBC-15021
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS101407
Guide to Pharmacology
7266
Ki Database
Phenelzine
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1200895
CHEMBL1089
Mcule NIBR MoA Box Subset
MCULE-2911295500
NCATS Inxight Approved Drugs
O408N561GF
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
phenelzine-sulfate
TargetMol Bioactive Compound Library
T12441
The Spectrum Collection
ZINC Tool Compounds
ZINC000019166991
External IDs
75
Properties
(calculated by RDKit )
Molecular Weight
136.1
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
3
Ring Count
1
Aromatic Ring Count
1
cLogP
0.69
TPSA
38.05
Fraction CSP3
0.25
Chiral centers
0.0
Largest ring
6.0
QED
0.47
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
MAO-A/B
Target
Monoamine Oxidase
ABAT, AOC3, GAD2, GPT, GPT2, MAOA, MAOB, SLC6A2, SLC6A3, SLC6A4
MAO
Pathway
Neuronal Signaling
Neuroscience
Member status
member
MOA
MAO Inhibitors
monoamine oxidase inhibitor
Indication
depression
Therapeutic Class
Antidepressants
Source data