General
Preferred name
Polydatin
Synonyms
(E/Z)-Piceid ()
Polydotin Peceid ()
Polydatin (Piceid) ()
PICEID27208-80-6 ()
(E/Z)-Polydatin ()
PICEID ()
Trans-Piceid ()
Resveratrol 3-.beta.-mono-d-glucoside ()
(E)-Polydatin ()
Trans-polydatin ()
(E)-Piceid ()
P&D ID
PD002913
CAS
27208-80-6
65914-17-2
148766-36-3
Tags
available
nuisance
drug
Approved by
FDA
Drug Status
approved
investigational
Max Phase
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
29
DESCRIPTION
(E/Z)-Polydatin ((E/Z)-Piceid) is the E/Z mixture of Polydatin (HY-N0120A). Polydatin is a monocrystalline compound originally isolated from the root and rhizome of Polygonum cuspidatum. (E/Z)-Polydatin has anti-platelet aggregation, anti-oxidative action of low-density lipoprotein (LDL), cardioprotective activity, anti-inflammatory and immune-regulating functions[1].
DESCRIPTION
Polydatin (Piceid), extracted from the roots of Reynoutria japonica, a widely used traditional Chinese remedies, possesses anti-inflammatory activity in several experimental models. Polydatin (Piceid) inhibits G6PD and induces oxidative and ER stresses.
DESCRIPTION
(E/Z)-Polydatin (Polydatin), is a natural precursor and glycoside form of resveratrol with a monocrystalline structure. While it is isolated from the bark of Picea sitchensis or Polygonum cuspidatum, Polydatin may be detected in grape, peanut, hop cones, red wines, hop pellets, cocoa-containing products, chocolate products and many daily diets. Polydatin possesses anti-inflammatory, immunoregulatory, anti-oxidative and anti-tumor activities. It is shown to mediate a cytotoxic action on colorectal cancer cells by inducing cell arrest and apoptosis.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
3
Organisms
0
Compound Sets
16
AdooQ Bioactive Compound Library
Cayman Chemical Bioactives
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
JUMP-Target 1 Compound Set
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
Nuisance compounds in cellular assays
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
44
Molecular Weight
390.13
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
6
Rotatable Bonds
5
Ring Count
3
Aromatic Ring Count
2
cLogP
0.45
TPSA
139.84
Fraction CSP3
0.3
Chiral centers
5.0
Largest ring
6.0
QED
0.4
Structural alerts
1
Nonspecific/NOS
Resveratrols
Nuisance compounds
Related compounds
Custom attributes
(extracted from source data)
Target
PLA2
ICAM1
Apoptosis
Autophagy
Mitophagy
Phospholipase (e.g. PLA)
Member status
virtual
MOA
VCAM1 Expression Inhibitors
ICAM1 Expression Inhibitors
Xanthine Oxidase Inhibitors
ICAM1 expression inhibitor
Pathway
Metabolism
Source data
