General
Preferred name
prednisolone
Synonyms
NSC-9900 ()
Prednisolone (NSC-9900) ()
Delta-cortef ()
Prednisolona ()
Neo-Delta-Cortef ()
Equisolon ()
Dekotil ()
Fernisolone-p ()
Hydeltra ()
Prednisolone component of chloroptic-p s.o.p. ()
Scheriproct ()
Prelone ()
Precortisyl fte ()
Meti-derm ()
Dilacort ()
Deltalone ()
Precortisyl ()
Sterane ()
Pred-G ()
Cortalone ()
Deltacortril ()
NSC-9120 ()
Pevanti ()
Poly-Pred ()
Prednisolone-d7 ()
P&D ID
PD002902
CAS
50-24-8
Tags
available
probe
drug
Approved by
FDA
First approval
1955
Drug indication
Multiple sclerosis
Eye inflammation
Solid tumour/cancer
Drug Status
vet_approved
approved
Max Phase
4.0
Probe info
Probe type
experimental probe
Probe sources
Chemical Probes.org
Probe targets
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Prednisolone is a synthetic glucocorticoid. Marketed formulations may contain prednisolone sodium phosphate, prednisolone acetate, prednisolone hexanoate or prednisolone. (GtoPdb)
DESCRIPTION Prednisolone is a potent, orally active corticosteroid and a glucocorticoid. Prednisolone possesses about four times the anti-inflammatory activity of hydrocortisone while causing less salt and water retention. Prednisolone can be used for ocular, anti-inflammatory research[1][2].
MOA Agonist (Chemical Probes.org)
DESCRIPTION Prednisolone is a glucocorticoid used to treat adrenocortical insufficiency, inflammatory conditions, and some cancers. Corticosteroids bind to the glucocorticoid receptor, inhibiting pro-inflammatory signals, and promoting anti-inflammatory signals. (Enamine Bioactive Compounds)
Cell lines
11
Organisms
1
Compound Sets
26
Cayman Chemical Bioactives
20866
35162
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL131
ChEMBL Drugs
CHEMBL131
Chemical Probes.org
prednisolone
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB00860
DrugBank Approved Drugs
DB00860
DrugCentral
2245
DrugCentral Approved Drugs
2245
DrugMAP
DMQ8FR2
DrugMAP Approved Drugs
DMQ8FR2
Enamine Bioactive Compounds
EBC-12796
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS101333
Guide to Pharmacology
2866
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL131
MedChem Express Bioactive Compound Library
HY-17463
NCATS Inxight Approved Drugs
9PHQ9Y1OLM
NIH Clinical Collections (NCC)
NPC Screening Collection
NURSA ligand set
nursa/index.jsf?doi=10.1621%2FW5MHAZ4ZDP
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Prednisolone(Hydroretrocortine)
External IDs
56
Properties
(calculated by RDKit )
Molecular Weight
360.19
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
3
Rotatable Bonds
2
Ring Count
4
Aromatic Ring Count
0
cLogP
1.56
TPSA
94.83
Fraction CSP3
0.71
Chiral centers
7.0
Largest ring
6.0
QED
0.69
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
Glucocorticoid Receptor agonist
Target
Glucocorticoid Receptor
NR3C1, NR3C2, SERPINA6
Endogenous Metabolite
Glucocorticoid Receptor,Immunology & Inflammation related
NR3C1
Disease Area
ophthalmology, dermatology, infectious disease
Indication
conjunctivitis, rosacea, punctate keratitis, shingles, iritis, cyclitis
Therapeutic Class
Anticancer Agents
Pathway
Immunology/Inflammation
Metabolic Enzyme/Protease
Vitamin D Related/Nuclear Receptor
Target class
Nuclear Receptor
Target subclass
Nuclear Hormone Receptor
Source data