General
Preferred name
quinidine
Synonyms
QUINIDINE GLUCONATE ()
Chinidin Sodium, Pitayine Sodium, β-quinine Sodium, (+)-quinidine Sodium ()
Quinidine hydrochloride monohydrate ()
Chinidin Sodium, Pitayine Sodium, ??quinine Sodium, (+)-quinidine Sodium ()
Quinidine (15% dihydroquinidine) ()
Chinidin Sodium, Pitayine Sodium, ¦Â-quinine Sodium, (+)-quinidine Sodium ()
Quinidine sulfate dihydrate ()
Conquinine ()
Quinidine hemisulfate hydrate ()
Quinidine sulfate ()
Quinatime ()
Quinidine monogluconate, d- ()
NSC-757297 ()
Duraquin ()
Quinaglute ()
Quinalan ()
Quinact ()
Gluconic acid quinidine salt ()
Dura-tab ()
Quinidine mono-d-gluconate ()
Gluquinate ()
(8r,9s)-quinidine ()
Kinidin ()
Pitayine ()
.beta.-quinidine ()
Quinidine sulfate anhydrous ()
Quinidine, sulfate (2:1) (salt) ()
NSC-10004 ()
Quinidini sulfas ()
Quinicardine ()
Quinidine sulfate hydrate ()
Quinidine sulphate dihydrate ()
Quinidine sulfate component of nuedexta ()
Quinidine sulphate ()
Quinidine sulphate anhydrous ()
QUINIDINE SULFATE COMPONENT OF AVP-786 ()
Quinidex ()
Quinora ()
Quinidex extentabs ()
Cin-Quin ()
Quinindine ()
Quinidine-d3 ()
(8R,9S)-QUINIDINE ()
.BETA.-QUINIDINE ()
KINIDIN ()
PITAYINE ()
P&D ID
PD002895
CAS
7054-25-3
6591-63-5
101143-86-6
56-54-2
6151-40-2
1267657-68-0
Tags
available
probe
drug
natural product
Approved by
FDA
First approval
1962
1950
Drug Status
approved
investigational
Max Phase
4.0
Drug indication
autism
cardiac arrhythmia
Malaria
Probe info
Probe type
calculated probe
Probe sources
Probe targets
[[ compound.targets[t].gene_name ]]
Probe control
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
29
DESCRIPTION
Quinidine hydrochloride monohydrate is an anti-arrythmic agent which is also a potent blocker of K+ channel with an IC50 of 19.9 ¦ÌM.
DESCRIPTION
Quinidine is a stereoisomer of . It acts as a class I antiarrhythmic agent, blocking the fast inward sodium current (INa).
DESCRIPTION
Quinidine is a stereoisomer of . It acts as a class I antiarrhythmic agent, blocking the fast inward sodium current (INa).
The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY. (GtoPdb)
The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY. (GtoPdb)
DESCRIPTION
Quinidine (15% dihydroquinidine) is an antiarrhythmic agent. Quinidine is a potent, orally active, selective cytochrome P450db inhibitor. Quinidine is also a K+ channel blocker with an IC50 of 19.9 ¦ÌM, and can induce apoptosis. Quinidine can be used for malaria research[1][2][3][4].
PRICE
29
DESCRIPTION
Quinidine hydrochloride monohydrate is an optical isomer of quinine, extracted from the bark of the Cinchona tree and similar plant species. It prolongs cellular action potential and decreases automaticity. This alkaloid dampens the excitability of cardiac and skeletal muscles by blocking sodium and potassium currents across cellular membranes. Quinidine also blocks muscarinic and alpha-adrenergic neurotransmission.
(TargetMol Bioactive Compound Library)
DESCRIPTION
Conquinine is a Cytochrome P450 2D6 inhibitor. It is a dextrorotatory stereoisomer of quinine extracted from the bark of the Cinchona tree and similar plant species. It is an alkaloid with class 1A antiarrhythmic and antimalarial effects. It also blocks muscarinic and alpha-adrenergic neurotransmission. It stabilizes the neuronal membrane by binding to and inhibiting voltage-gated sodium channels, thus inhibiting the sodium influx required for the initiation and conduction of impulses resulting in an increase of the threshold for excitation and decreased depolarization during phase 0 of the action potential. It acts primarily as an intra-erythrocytic schizonticide through association with the heme polymer (hemazoin) in the acidic food vacuole of the parasite thereby preventing further polymerization by heme polymerase enzyme.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Quinidine is a stereoisomer of the antimalarial agent quinine. Quinidine blocks the potassium voltage-gated channel. It is used to restore normal sinus rhythm, treat atrial fibrillation and flutter, and treat ventricular arrhythmias.
(Enamine Bioactive Compounds)
DESCRIPTION
Quinidine is a stereoisomer of the antimalarial agent quinine and a class Ia antiarrhythmic agent. for the treatment of abnormal heart rhythms and also malaria.
(TargetMol Bioactive Compound Library)
DESCRIPTION
Quinidine is a voltage-gated sodium channel blocker, exhibiting antimuscarinic and antimalarial properties.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
2
Organisms
4
Compound Sets
30
BOC Sciences Bioactive Compounds
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
Enamine Bioactive Compounds
Enamine BioReference Compounds
EUbOPEN Chemogenomics Library
Guide to Pharmacology
JUMP-Target 1 Compound Set
LSP-MoA library (Laboratory of Systems Pharmacology)
NCATS Inxight Approved Drugs
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
Probe Miner (suitable probes)
Selleckchem Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
94
Molecular Weight
324.18
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
5
Aromatic Ring Count
2
cLogP
3.17
TPSA
45.59
Fraction CSP3
0.45
Chiral centers
5.0
Largest ring
6.0
QED
0.88
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Parasite
Potassium Channel
Sodium Channel
KCNA5, KCNA7, KCNH1, KCNH2, KCNH5, KCNK1, KCNK6, SCN5A, SLC29A4
KCNK1
Apoptosis
Cytochrome P450
Member status
member
MOA
P-Glycoprotein (MDR-1) Inhibitors
Sodium Channel inhibitor
Sodium Channel blocker
Indication
malaria, atrial fibrillation (AF), ventricular arrhythmias
Disease Area
infectious disease, cardiology
Pathway
Membrane Transporter/Ion Channel
Microbiology/virology
Anti-infection
Metabolic Enzyme/Protease
Solubility
0.05 g/100 mL
Recommended Cell Concentration
None
Source data
