General
Preferred name
SIBUTRAMINE
Synonyms
Sibutramine HCl ()
SIBUTRAMINE HYDROCHLORIDE ()
Sibutramine (hydrochloride monohydrate) ()
(¡À)-Sibutramine (methanesulfonate) ()
BTS 54-524 hydrochloride monohydrate ()
BTS 54-524 ()
Meridia ()
BTS-54524 ()
Medaria ()
Butramin ()
Reductil ()
Cf-alli ()
Racemic sibutramine ()
Sibutramina ()
NSC-758928 ()
BTS 54524 ()
Sibutramine hydrochloride hydrate ()
Sibutramine hydrochloride civ ()
Sibutramine hydrochloride monohydrate ()
Sibutramine (hydrochloride) ()
P&D ID
PD002864
CAS
84485-00-7
106650-56-0
125494-59-9
Tags
available
drug
Approved by
FDA
First approval
1997
Drug indication
Obesity
Anorexic
Antidepressant
Drug Status
investigational
illicit
approved
withdrawn
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Use of sibutramine is reported to increase risk of heart attack and stroke in patients with a history of heart disease. For this reason sibutramine has been withdrawn from use in some countries.
(GtoPdb)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
24
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Guide to Pharmacology
Ki Database
LSP-MoA library (Laboratory of Systems Pharmacology)
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Other bioactive compounds
Prestwick Chemical Library
ReFrame library
Withdrawn 2.0
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
68
Molecular Weight
279.18
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
0
Rotatable Bonds
5
Ring Count
2
Aromatic Ring Count
1
cLogP
4.74
TPSA
3.24
Fraction CSP3
0.65
Chiral centers
1.0
Largest ring
6.0
QED
0.75
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Neuronal Signaling
Membrane Transporter/Ion Channel
Target
Serotonin Transporter
Potassium Channel
Member status
virtual
MOA
5-HT Reuptake Inhibitors
Norepinephrine Transporter (NET) Inhibitors
ATC
A08AA10
Toxicity type
cardiovascular
Therapeutic Class
Appetite Depressants
Source data
