General
Preferred name
SIBUTRAMINE
Synonyms
Sibutramine HCl ()
SIBUTRAMINE HYDROCHLORIDE ()
Sibutramine (hydrochloride monohydrate) ()
(¡À)-Sibutramine (methanesulfonate) ()
BTS 54-524 hydrochloride monohydrate ()
BTS 54-524 ()
BTS-54524 ()
Meridia ()
Reductil ()
Cf-alli ()
Butramin ()
Medaria ()
Racemic sibutramine ()
BTS 54524 ()
NSC-758928 ()
Sibutramine hydrochloride civ ()
Sibutramine hydrochloride monohydrate ()
Sibutramine hydrochloride hydrate ()
Sibutramine (hydrochloride) ()
P&D ID
PD002864
CAS
84485-00-7
106650-56-0
125494-59-9
Tags
natural product
drug
available
Approved by
FDA
First approval
1997
Drug Status
illicit
investigational
approved
withdrawn
Drug indication
Obesity
Anorexic
Antidepressant
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Use of sibutramine is reported to increase risk of heart attack and stroke in patients with a history of heart disease. For this reason sibutramine has been withdrawn from use in some countries.
(GtoPdb)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
24
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Guide to Pharmacology
Ki Database
LSP-MoA library (Laboratory of Systems Pharmacology)
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Other bioactive compounds
Prestwick Chemical Library
ReFrame library
Withdrawn 2.0
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
69
Molecular Weight
279.18
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
0
Rotatable Bonds
5
Ring Count
2
Aromatic Ring Count
1
cLogP
4.74
TPSA
3.24
Fraction CSP3
0.65
Chiral centers
1.0
Largest ring
6.0
QED
0.75
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Neuronal Signaling
Membrane Transporter/Ion Channel
Target
Serotonin Transporter
Potassium Channel
Member status
virtual
MOA
5-HT Reuptake Inhibitors
Norepinephrine Transporter (NET) Inhibitors
ATC
A08AA10
Toxicity type
cardiovascular
Therapeutic Class
Appetite Depressants
Source data
