General
Preferred name
TOCAINIDE
Synonyms
TOCAINIDE HYDROCHLORIDE ()
2-amino-n-(2,6-dimethylphenyl)propanamide hydrochloride ()
Tocainide (hydrochloride) ()
Tocainide monohydrochloride ()
Tocainide hcl ()
Tonocard ()
Tocainide (+/-)-form hydrochloride ()
Xylotocan ()
W-36095 ()
Tocainida ()
Tocainide ()
P&D ID
PD002838
CAS
35891-93-1
41708-72-9
53984-26-2
76213-25-7
71395-14-7
Tags
available
drug
Approved by
FDA
First approval
1984
Drug indication
Ventricular arrhythmias
cardiac arrhythmia
Drug Status
approved
withdrawn
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Tocainide hydrochloride is a sodium channel blocker, it blocks the sodium channels in the pain-producing foci in the nerve membranes. Tocainide hydrochloride is a primary amine analog of lidocaine, can be used for the treatment of tinnitus[1][2].
PRICE 50
DESCRIPTION Tocainide is a lidocaine analog. (GtoPdb)
DESCRIPTION Tocainide hydrochloride is an orally activesodium channel blocker, it blocks the sodium channels in the pain-producing foci in the nerve membranes. Tocainide hydrochloride is a primary amine analog of lidocaine, can be used for the treatment of tinnitus[1][2].
PRICE 29
DESCRIPTION Sodium channel blocker. Class IB antiarrhythmic. (LOPAC library)
DESCRIPTION Tocainide is an orally active class 1b antiarrhythmic agent that interferes with cardiac sodium channels. It is used for the treatment of documented ventricular arrhythmias, such as sustained ventricular tachycardia, that, in the judgment of the physician, are life-threatening. (Enamine Bioactive Compounds)
DESCRIPTION Tocainide hydrochloride (2-amino-n-(2,6-dimethylphenyl)propanamide hydrochloride) is a sodium channel blocker. It blocks the sodium channels in the pain-producing foci in the nerve membranes. (TargetMol Bioactive Compound Library)
DESCRIPTION Tocainide is a blocker of the sodium channel and used for the treatment of tinnitus. (TargetMol Bioactive Compound Library)
Compound Sets
21
Cayman Chemical Bioactives
41592
ChEMBL Approved Drugs
CHEMBL1200773
CHEMBL1762
ChEMBL Drugs
CHEMBL1200773
CHEMBL1762
DrugBank
DB01056
DrugBank Approved Drugs
DB01056
DrugCentral
2686
DrugCentral Approved Drugs
2686
DrugMAP
DMYNMDP
DrugMAP Approved Drugs
DMYNMDP
DrugMatrix
Enamine Bioactive Compounds
EBC-03621
Enamine BioReference Compounds
Guide to Pharmacology
7309
LOPAC library
MedChem Express Bioactive Compound Library
HY-B1798A
HY-B1798
NIH Clinical Collections (NCC)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
TargetMol Bioactive Compound Library
T9234
T13177L
Withdrawn 2.0
500
External IDs
48
Properties
(calculated by RDKit )
Molecular Weight
192.13
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
2
Ring Count
1
Aromatic Ring Count
1
cLogP
1.59
TPSA
55.12
Fraction CSP3
0.36
Chiral centers
1.0
Largest ring
6.0
QED
0.75
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Sodium Channel
ATC
C01BB03
Therapeutic Class
Antiarrhythmic Agents
Pathway
Membrane Transporter/Ion Channel
Source data