General
Preferred name
TRYPTOLINE
Synonyms
Tetrahydro-β-carboline ()
Tetrahydro-¦Â-carboline ()
1,2,3,4-Tetrahydro-?-carboline ()
P&D ID
PD002831
CAS
16502-01-5
Tags
available
drug candidate
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Tetrahydro-¦Â-carboline (Tryptoline) is a metabolite of tryptamine, also is a competitive serotonin reuptake inhibitor with an Ki value of 6.1 ¦ÌM[1].
DESCRIPTION Tetrahydro-β-carboline is a metabolite of tryptamine. It has high affinity to imidazoline 2-sites. Tetrahydro-β-carboline also is a competitive serotonin reuptake inhibitor. (Enamine Bioactive Compounds)
Compound Sets
5
Cayman Chemical Bioactives
35038
DrugMAP
DMV19K7
Enamine Bioactive Compounds
EBC-47289
MedChem Express Bioactive Compound Library
HY-20696
NIH Clinical Collections (NCC)
External IDs
30
Properties
(calculated by RDKit )
Molecular Weight
172.1
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
2
Rotatable Bonds
0
Ring Count
3
Aromatic Ring Count
2
cLogP
1.81
TPSA
27.82
Fraction CSP3
0.27
Chiral centers
0.0
Largest ring
6.0
QED
0.62
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
5-HT Receptor
Pathway
GPCR/G protein
Neuronal Signaling
Source data