General
Preferred name
RACEMETYROSINE
Synonyms
METYROSINE ()
DL-alpha-Methyl-p-tyrosine ()
SM-88 ()
α-Methyl-p-tyrosine ()
Racemetirosine ()
methyltyrosine ()
.alpha.-methyl-p-tyrosine ()
DNP-01 ()
L1-79 ()
Dl-2-methyl-p-tyrosine ()
RACEMETYROSINE COMPONENT OF SM-88 ()
D,l-metyrosine ()
Tyrosine, .alpha.-methyl- ()
.alpha.-methyltyrosine ()
Dl-metyrosine ()
Racemetirosina ()
Alpha-methyl-p-tyrosine ()
P&D ID
PD002829
CAS
620-30-4
658-48-0
Tags
available
drug
Drug indication
Pancreatic cancer
pancreatic carcinoma
Prostate cancer
Drug Status
approved
investigational
Max Phase
3.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 29
DESCRIPTION The INN for this compound is racemetirosine, indicating that it is a racemic mix of its R and S enantiomers. We show the non-isomeric structure to represent this mixture. The website rxlist.com describes the approved drug, Demser, as (-)-α-methyl-L-tyrosine, but shows a non-stereo molecular structure. We have annotated both versions (racemic and S-enantiomer (L or α) with the same US FDA approval date, as the exact compostion of the approved drug is unclear. (GtoPdb)
DESCRIPTION Inhibitor of catecholamine synthesis and tyrosine hydroxylase (LOPAC library)
DESCRIPTION Racemetirosine is a Tyrosine 3-monooxygenase inhibitor, and inhibits the synthesis of catecholamines consequently. (TargetMol Bioactive Compound Library)
Compound Sets
10
ChEMBL Drugs
CHEMBL1330596
Concise Guide to Pharmacology 2017/18
5094
DrugBank
DB16306
DrugMAP
DMD9ISG
DrugMatrix
Guide to Pharmacology
5094
LOPAC library
MedChem Express Bioactive Compound Library
HY-33549
NPC Screening Collection
TargetMol Bioactive Compound Library
T20700
External IDs
31
Properties
(calculated by RDKit )
Molecular Weight
195.09
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
3
Rotatable Bonds
3
Ring Count
1
Aromatic Ring Count
1
cLogP
0.74
TPSA
83.55
Fraction CSP3
0.3
Chiral centers
1.0
Largest ring
6.0
QED
0.66
Structural alerts
2
aggregator (Aggregator Advisor)
Aggregators
aggregator (ZINC)
Aggregators
Related compounds
Custom attributes
(extracted from source data)
Selectivity
Tyrosine hydroxylase
Target
Tyrosine 3-monooxygenase
Tyrosine Hydroxylase
Pathway
Metabolic Enzyme/Protease
Source data