General
Preferred name
GAMMA-AMINOBUTYRIC ACID
Synonyms
gamma-AMINOBUTYRIC ACID HYDROCHLORIDE ()
4-Aminobutyric acid ()
GABA ()
¦Ã-Aminobutyric acid ()
4-Aminobutanoic acid ()
Piperidic acid ()
aminobutyric acid ()
??Aminobutyric acid ()
GSK683699 ()
SARGRAMOSTIM ()
γ-Aminobutyric acid ()
4-Aminobutanoic acid, GABA, Gamma-aminobutyric acid, Piperidic acid ()
4-Aminobutyric acid (GABA) ()
[3H]GABA ()
.gamma.-aminobutyric acid ()
Aminobutyric acid, gamma- ()
Butyric acid, 4-amino- ()
Factor i ()
.gamma.-amino-butyric acid ()
.gamma.-amino-n-butyric acid ()
NSC-27418 ()
Gamma-aminobutyrate ()
Vigabatrin impurity, .gamma.-aminobutyric acid- ()
4-Amino-n-butyric acid ()
??-Aminobutyric acid ()
P&D ID
PD002827
CAS
56-12-2
3131-86-0
28805-76-7
20-79-1
5959-35-3
123774-72-1
Tags
available
drug
Approved by
FDA
Drug indication
Epilepsy
Inflammatory bowel disease
Drug Status
approved
investigational
Max Phase
1.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
29
DESCRIPTION
??-Aminobutyric acid (4-Aminobutyric acid) is the predominant inhibitory neurotransmitter in the central nervous system.
DESCRIPTION
Endogenous neurotransmitter
(LOPAC library)
DESCRIPTION
Potent AMPA antagonist; more selective than CNQX (Cat. No. 0190)
(Tocris Bioactive Compound Library)
DESCRIPTION
4-amino-n-butyric acid is a stimulator of GABA receptors.
(Enamine Bioactive Compounds)
DESCRIPTION
γ-Aminobutyric acid (4-Aminobutyric acid) is the predominant inhibitory neurotransmitter in the central nervous system.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
29
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMatrix
Enamine Bioactive Compounds
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
Ki Database
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
Mcule NIBR MoA Box Subset
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
77
Molecular Weight
103.06
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
3
Ring Count
0
Aromatic Ring Count
0
cLogP
-0.19
TPSA
63.32
Fraction CSP3
0.75
Chiral centers
0.0
Largest ring
0.0
QED
0.52
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Endogenous Metabolite
GABA
GABA Receptor
GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA5, GABRB2, GABRG2, GATM, KCTD12, KCTD16, KCTD8, SLC6A1
Primary Target
GABAA Receptors
MOA
Agonist
benzodiazepine receptor agonist
Member status
member
Pathway
Membrane Transporter/Ion Channel
Metabolism
Neuroscience
Metabolic Enzyme/Protease
Neuronal Signaling
Source data
