General
Preferred name
ARGININE
Synonyms
L-arginine ()
(S)-(+)-Arginine ()
L-Arg ()
NSC-206269 ()
P&D ID
PD002820
CAS
74-79-3
17806-42-7
4455-52-1
25212-18-4
142-49-4
Tags
covalent binder
natural product
drug
available
Approved by
PMDA
EMA
FDA
First approval
1973
Drug indication
Ammonia Detoxicant
Growth hormone deficiency
Diagnostic Aid (pituitary function determination)
Drug Status
nutraceutical
investigational
approved
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Nitric oxide precursor (LOPAC library)
DESCRIPTION Inhibits NF-kappaB, prevents increase in NOS mRNA (Tocris Bioactive Compound Library)
Compound Sets
24
ChEMBL Approved Drugs
CHEMBL1485
ChEMBL Drugs
CHEMBL1485
Concise Guide to Pharmacology 2017/18
721
Concise Guide to Pharmacology 2019/20
721
Concise Guide to Pharmacology 2021/22
721
Concise Guide to Pharmacology 2023/24
721
CovBinderInPDB
CBR000200
CBR000199
Drug Repurposing Hub
DrugBank
DB00125
DrugCentral
1549
DrugCentral Approved Drugs
1549
DrugMAP
DMRE4FC
DrugMAP Approved Drugs
DMRE4FC
Enamine BioReference Compounds
Guide to Pharmacology
721
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1485
MedChem Express Bioactive Compound Library
HY-N0455
NCATS Inxight Approved Drugs
94ZLA3W45F
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
l-arginine
TargetMol Bioactive Compound Library
T3S0364
Tocris Bioactive Compound Library
0663
External IDs
62
Properties
(calculated by RDKit )
Molecular Weight
174.11
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
5
Rotatable Bonds
5
Ring Count
0
Aromatic Ring Count
0
cLogP
-1.34
TPSA
125.22
Fraction CSP3
0.67
Chiral centers
1.0
Largest ring
0.0
QED
0.2
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Immunology/Inflammation
Metabolic Enzyme/Protease
Target
IL-2
ARG2, ASL, ASS1, AZIN2, GPRC6A, NOS2, NOS3, SLC7A1, SLC7A3, SLC7A4
Endogenous Metabolite
NO Synthase
Primary Target
NO Donors / Precursors
MOA
IL receptor
nitric oxide precursor
Disease Area
cardiology, neurology/psychiatry, urology, obstetrics/gynecology, otolaryngology
Indication
congestive heart failure, hypertension, coronary artery disease (CAD), claudication, senile dementia, erectile dysfunction, infertility, common cold
Source data