General
Preferred name
ARGININE
Synonyms
L-arginine ()
L-Arg ()
(S)-(+)-Arginine ()
NSC-206269 ()
Arginina ()
P&D ID
PD002820
CAS
74-79-3
17806-42-7
4455-52-1
25212-18-4
142-49-4
Tags
available
covalent binder
drug
Approved by
EMA
PMDA
FDA
First approval
1973
Drug indication
Growth hormone deficiency
Glioblastoma multiforme
Drug Status
approved
investigational
nutraceutical
Max Phase
3.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 29
DESCRIPTION L-Arginine is an essential amino acid for human development and a precursor for nitric oxide. L-Arginine is transported into vascular smooth muscle cells by the cationic amino acid transporter family of proteins where it is metabolized to nitric oxide, polyamines, or L-proline. (Enamine Bioactive Compounds)
DESCRIPTION Nitric oxide precursor (LOPAC library)
DESCRIPTION 1. L-Arginine (L-Arg) exhibits anti-atherosclerotic effect. 2. L-Arginine and soy enriched diet are effective in prevention of osteoporosis associated with diabetes mellitus. 3. Exogenous L-Arginine could enhance neonate lymphocyte proliferation through an interleukin-2-independent pathway. 4. A combination of oral L-citrulline and L-Arginine effectively and rapidly augments NO-dependent responses at the acute stage. (TargetMol Bioactive Compound Library)
DESCRIPTION Inhibits NF-kappaB, prevents increase in NOS mRNA (Tocris Bioactive Compound Library)
Compound Sets
24
ChEMBL Drugs
CHEMBL1485
Concise Guide to Pharmacology 2017/18
721
Concise Guide to Pharmacology 2019/20
721
Concise Guide to Pharmacology 2021/22
721
Concise Guide to Pharmacology 2023/24
721
CovBinderInPDB
CBR000200
CBR000199
Drug Repurposing Hub
DrugBank
DB00125
DrugCentral
1549
DrugCentral Approved Drugs
1549
DrugMAP
DMRE4FC
DrugMAP Approved Drugs
DMRE4FC
Enamine Bioactive Compounds
EBC-13718
Enamine BioReference Compounds
Guide to Pharmacology
721
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1485
MedChem Express Bioactive Compound Library
HY-N0455
NCATS Inxight Approved Drugs
94ZLA3W45F
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
l-arginine
TargetMol Bioactive Compound Library
T3S0364
Tocris Bioactive Compound Library
0663
External IDs
66
Properties
(calculated by RDKit )
Molecular Weight
174.11
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
5
Rotatable Bonds
5
Ring Count
0
Aromatic Ring Count
0
cLogP
-1.34
TPSA
125.22
Fraction CSP3
0.67
Chiral centers
1.0
Largest ring
0.0
QED
0.2
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Endogenous Metabolite
IL-2
NO Synthase
ARG2, ASL, ASS1, AZIN2, GPRC6A, NOS2, NOS3, SLC7A1, SLC7A3, SLC7A4
Primary Target
NO Donors / Precursors
MOA
IL receptor
nitric oxide precursor
Disease Area
cardiology, neurology/psychiatry, urology, obstetrics/gynecology, otolaryngology
Indication
congestive heart failure, hypertension, coronary artery disease (CAD), claudication, senile dementia, erectile dysfunction, infertility, common cold
Pathway
Immunology/Inflammation
Metabolism
Metabolic Enzyme/Protease
Source data