General
Preferred name
CINNARIZINE
Synonyms
Dimitronal ()
Stutgin ()
Cinarizine ()
Stugeron ()
Stugeron|Dimitronal|Stutgin|Cinarizine ()
Stugeron, Dimitronal, Stutgin, Cinarizine ()
Cerepar ()
Mylan Travel Sickness ()
Stutgeron ()
Eglen ()
Carecin ()
Katoseran ()
R-1575 ()
Denapol ()
R 1575 ()
Processine ()
Labyrin ()
Midronal ()
Olamin ()
516-MD ()
Glanil ()
NSC-758400 ()
Cinaperazine ()
Corathiem ()
Ixertol ()
Stugeron Fte ()
Cinarizina ()
R-516 ()
Spaderizine ()
Marzine R.F. ()
Aplactan ()
Hilactan ()
Siptazin ()
Sepan ()
Stunarone ()
Cerebolan ()
Cinnacet ()
Cinazyn ()
Cinnageron ()
Dimitron ()
Artate ()
516 MD ()
Aplexal ()
Folcodal ()
R 516 ()
Sedatromin ()
Giganten ()
Cinnipirine ()
Mitronal ()
P&D ID
PD002810
CAS
298-57-7
16699-20-0
Tags
available
drug
Drug indication
Vertigo meniere disease
Antihistaminic
Drug Status
investigational
approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Cinnarizine is used primarily for its anti-histaminic activity, but it also has anti-cholinergic and calcium channel blocking effects, which may account for some of its side-effects.The INN record for this drug specifies cinnarizine clofibrate (PubChem CID 6436096). Cinnarizine is the parent molecule of the fluorine derivative . Both of these compounds induce parkinsonism as an adverse effect , likely due to antagonism of D2 receptors by the parent molecules and/or some of their bioactive metabolites . (GtoPdb)
DESCRIPTION Ca2+ channel blocker; central and peripheral vasodilator (LOPAC library)
Cell lines
4
Organisms
1
Compound Sets
19
Cayman Chemical Bioactives
21001
ChEMBL Approved Drugs
CHEMBL43064
ChEMBL Drugs
CHEMBL43064
Drug Repurposing Hub
DrugBank
DB00568
DrugBank Approved Drugs
DB00568
DrugCentral
654
DrugCentral Approved Drugs
654
DrugMAP
DM7U5QJ
DrugMAP Approved Drugs
DM7U5QJ
Guide to Pharmacology
9072
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL43064
MedChem Express Bioactive Compound Library
HY-B1090
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
cinnarizine
TargetMol Bioactive Compound Library
T0903
External IDs
36
Properties
(calculated by RDKit )
Molecular Weight
368.23
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
6
Ring Count
4
Aromatic Ring Count
3
cLogP
5.11
TPSA
6.48
Fraction CSP3
0.23
Chiral centers
0.0
Largest ring
6.0
QED
0.6
Structural alerts
2
aggregator (ZINC)
Aggregators
aggregator (Aggregator Advisor)
Aggregators
Related compounds
Custom attributes
(extracted from source data)
Pathway
GPCR/G protein
Membrane Transporter/Ion Channel
Immunology/Inflammation
Neuroscience
Neuronal Signaling
Target
Calcium Channel
H1 receptor
Histamine Receptor
Indication
Meniere's disease, nausea, vomiting, Cogan's syndrome
Disease Area
neurology/psychiatry, gastroenterology, ophthalmology
MOA
calcium channel blocker
Therapeutic Class
Antiallergic Agents
Source data