General
Preferred name
CGS 15943
Synonyms
CGS-15943 ()
CGS 15943 ()
P&D ID
PD002809
CAS
104615-18-1
Tags
natural product
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Highly potent, non-selective A1 adenosine receptor antagonist (LOPAC library)
DESCRIPTION Potent and selective D1-like agonist; orally active (Tocris Bioactive Compound Library)
DESCRIPTION Potent adenosine receptor antagonist (Tocriscreen Total)
Cell lines
1
Organisms
2
Compound Sets
19
AdooQ Bioactive Compound Library
A14327
Cayman Chemical Bioactives
22073
Concise Guide to Pharmacology 2017/18
384
Concise Guide to Pharmacology 2019/20
384
Concise Guide to Pharmacology 2021/22
384
Concise Guide to Pharmacology 2023/24
384
Drug Repurposing Hub
Guide to Pharmacology
384
Ki Database
CGS 15943
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL16687
Mcule NIBR MoA Box Subset
MCULE-6159667172
MedChem Express Bioactive Compound Library
HY-100678
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
TargetMol Bioactive Compound Library
T14944
Tocris Bioactive Compound Library
1699
Tocriscreen Total
ZINC Tool Compounds
ZINC000003872013
External IDs
26
Properties
(calculated by RDKit )
Molecular Weight
285.04
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
1
Rotatable Bonds
1
Ring Count
4
Aromatic Ring Count
4
cLogP
2.77
TPSA
82.24
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.58
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
A1
Pathway
Neuroscience
PI3K/Akt/mTOR signaling
GPCR/G protein
PI3K/Akt/mTOR
Target
Adenosine A1?receptor
Adenosine A2a receptor
Adenosine A2b receptor
adenosine A3 receptor
p110??
ADORA1, ADORA2A, ADORA2B, ADORA3
Adenosine Receptor
PI3K
Primary Target
Non-selective Adenosine
MOA
Antagonist
Adenosine Receptor Antagonists
Adenosine Receptor antagonist
Member status
member
Source data