General
Preferred name
BP 897
Synonyms
Naphthalene-2-carboxylic acid {4-[4-(2-methoxy-phenyl)-piperazin-1-yl]-butyl}-amide ()
BP-897 ()
2-Naphthalenecarboxamide, N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]- ()
DO 897/99 ()
BP897 ()
BP4.897 ()
BP 897 (hydrochloride) ()
BP 897 hydrochloride ()
DO 897 ()
P&D ID
PD002798
CAS
314776-92-6
192384-87-5
Tags
available
drug candidate
Drug indication
Cocaine addiction
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION BP 897 is a partial agonist of the dopamine D3 receptor . (GtoPdb)
PRICE 214
DESCRIPTION BP 897 (2-Naphthalenecarboxamide, N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-) is a potent and selective dopamine D3 receptor agonist, and a weak dopamine D2 receptor antagonist, with Kis of 0.92 nM and 61 nM for D3 and D2 receptors, and shows low affinities at D1 and D4 receptors (Kis, 3 and 0.3 ??M, respectively).
DESCRIPTION BP 897 hydrochloride is a potent and partial dopamine D3 receptor agonist and a weak D2 receptor antagonist. BP 897 hydrochloride displays a high affinity at the dopamine D3 receptor (Ki=0.92 nM) and a 70 times lower affinity at the D2 receptor (Ki=61 nM)[1].
PRICE 63
DESCRIPTION BP 897 is a potent and selective agonist of dopamine D3 receptor and it is a weak dopamine D2 receptor antagonist, with Kis of 0.92 nM and 61 nM for D3 and D2 receptors. Which shows low affinities at D1 and D4 receptors (Kis, 3 and 0.3 ??M, respectively).
DESCRIPTION Partially selective D3 dopamine receptor agonist (LOPAC library)
DESCRIPTION DO 897 binds to d(3) dopamine receptor. It also has high binding affinity towards 5-hydroxytryptamine receptor 1a and apha 1 adrenergic receptor. (Enamine Bioactive Compounds)
DESCRIPTION BP 897 (2-Naphthalenecarboxamide, N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-) is a potent and selective dopamine D3 receptor agonist, and a weak dopamine D2 receptor antagonist, with Kis of 0.92 nM and 61 nM for D3 and D2 receptors, and shows low affinities at D1 and D4 receptors (Kis, 3 and 0.3 μM, respectively). (TargetMol Bioactive Compound Library)
DESCRIPTION BP 897 is a potent and selective agonist of dopamine D3 receptor and it is a weak dopamine D2 receptor antagonist, with Kis of 0.92 nM and 61 nM for D3 and D2 receptors. Which shows low affinities at D1 and D4 receptors (Kis, 3 and 0.3 μM, respectively). (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
2
Compound Sets
16
AdooQ Bioactive Compound Library
A12415
Cayman Chemical Bioactives
25831
Drug Repurposing Hub
DrugMAP
DMAQ6DS
Enamine Bioactive Compounds
EBC-47505
EUbOPEN Chemogenomics Library
EUB0000943
Guide to Pharmacology
7625
Ki Database
Naphthalene-2-carboxylic acid {4-[4-(2-methoxy-phenyl)-piperazin-1-yl]-butyl}-amide
BP-897
LOPAC library
Mcule NIBR MoA Box Subset
MCULE-8259942199
MedChem Express Bioactive Compound Library
HY-106660
Novartis Chemogenetic Library (NIBR MoA Box)
Other bioactive compounds
ReFrame library
TargetMol Bioactive Compound Library
T9100
T14767
ZINC Tool Compounds
ZINC000003917109
External IDs
37
Properties
(calculated by RDKit )
Molecular Weight
417.24
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
8
Ring Count
4
Aromatic Ring Count
3
cLogP
4.18
TPSA
44.81
Fraction CSP3
0.35
Chiral centers
0.0
Largest ring
6.0
QED
0.56
QED
0.56
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
D3
Target
D1
D2
D4
dopamine
ADRA1A, ADRA1D, ADRA2A, DRD1, DRD2, DRD3, DRD4, HTR1A, HTR2B
Dopamine Receptor
Member status
member
MOA
Dopamine D3 Agonists
Dopamine Receptor agonist
Pathway
GPCR/G protein
Neuronal Signaling
Neuroscience
Recommended Cell Concentration
100 nM
Source data