General
Preferred name
SB 202190
Synonyms
FHPI ()
SB202190 ()
SB-202190 ()
Oxindole 94 ()
SB 202190 (hydrochloride) ()
SB 202190 hydrochloride ()
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole ()
SB202190 (FHPI) ()
SB 202190 (hydrochloride) ()
P&D ID
PD002796
CAS
152121-30-7
350228-36-3
Tags
available
drug candidate
Drug indication
Pain
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION SB202190 is a potent and selective p38 MAPK inhibitor.
DESCRIPTION SB202190 is a potent and selective p38 MAPK inhibitor, that preferentially inhibits p38α and p38β. (GtoPdb)
DESCRIPTION Phospholipase C inhibitor (Tocris Bioactive Compound Library)
DESCRIPTION Highly selective, potent and cell permeable p38 MAP kinase inhibitor. (LOPAC library)
DESCRIPTION Potent, selective inhibitor of p38 MAPK (Tocriscreen Total)
DESCRIPTION Potent, selective inhibitor of p38 MAPK (Tocriscreen Plus)
DESCRIPTION SB 202190 is a potent, selective, and cell-permeable inhibitor of p38 MAP kinases, effective against p38α (SAPK2A, MAPK14) and p38β (SAPK2B, MAPK11) with IC50 values of 50 and 100 nM, respectively. It inhibits p38 MAP kinases, resulting in blockade of tumor necrosis factor alpha (TNF-alpha) and interleukin-1beta (IL-1beta) production in monocytes. (BOC Sciences Bioactive Compounds)
Cell lines
1
Organisms
2
Compound Sets
20
Axon Medchem Screening Library
1364
BOC Sciences Bioactive Compounds
sb-202190-monohydrochloride-hydrate-cas-350228-36-3-item-188753
Cayman Chemical Bioactives
10010399
21201
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugMAP
DMPFD6Y
DrugMatrix
EU-OPENSCREEN Bioactive Compound Library
EOS101076
Guide to Pharmacology
4307
JUMP-Target 1 Compound Set
LINCS compound set
10441-101
LOPAC library
MedChem Express Bioactive Compound Library
HY-10295
HY-10295A
Novartis Chemogenetic Library (NIBR MoA Box)
Selleckchem Bioactive Compound Library
SB-202190
TargetMol Bioactive Compound Library
T2301
Tocris Bioactive Compound Library
1264
Tocriscreen Plus
1264
Tocriscreen Total
ZINC Tool Compounds
ZINC000089221712
External IDs
46
Properties
(calculated by RDKit )
Molecular Weight
331.11
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
3
Ring Count
4
Aromatic Ring Count
4
cLogP
4.65
TPSA
61.8
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.57
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Enzymes
Selectivity
p38 MAPK
Pathway
MAPK
Apoptosis
Autophagy
MAPK/ERK Pathway
Stem Cell/Wnt
Target
p38??
p38¦Á
p38¦Â
AKT1, ALOX5, CHEK1, GSK3B, LCK, MAPK1, MAPK11, MAPK12, MAPK14, MAPK8, PRKCA, ROCK1, RPS6KB1, SGK1
MAPK14
Organoid
Apoptosis related,Autophagy,Ferroptosis,p38 MAPK
MOA
Inhibitor
p38 alpha/beta inhibitor
p38 MAPK inhibitor
Member status
member
Source data