General
Preferred name
BRIVUDINE
Synonyms
(E)-5-(2-Bromovinyl)-2'-deoxyuridine ()
Bromovinyldeoxyuridine ()
BVDU ()
RP101 ()
brivudine eyedrop, Menarini ()
NSC-633770 ()
Brivudina ()
RP-101 ()
Brivudin ()
Zostex ()
P&D ID
PD002794
CAS
69304-47-8
Tags
available
prodrug
drug
Drug indication
Pancreatic cancer
Infectious disease
viral disease
Drug Status
approved
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Brivudine is a thymidine analogue with antiviral activity, indicated for the early treatment of acute herpes zoster.
PRICE 29
DESCRIPTION Potent inhibitor of herpes simplex type 1 (LOPAC library)
DESCRIPTION Brivudine (BVDU), an antiviral medicine, is used in the therapy of herpes zoster. (TargetMol Bioactive Compound Library)
Cell lines
4
Organisms
7
Compound Sets
17
Cayman Chemical Bioactives
29448
ChEMBL Drugs
CHEMBL31634
Drug Repurposing Hub
DrugBank
DB03312
DrugBank Approved Drugs
DB03312
DrugCentral
397
DrugCentral Approved Drugs
397
DrugMAP
DMNIYSZ
EU-OPENSCREEN Bioactive Compound Library
EOS100690
LOPAC library
MedChem Express Bioactive Compound Library
HY-13578
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
brivudine
TargetMol Bioactive Compound Library
T0718
ZINC Tool Compounds
ZINC000003653378
External IDs
40
Properties
(calculated by RDKit )
Molecular Weight
332.0
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
3
Rotatable Bonds
3
Ring Count
2
Aromatic Ring Count
1
cLogP
-0.46
TPSA
104.55
Fraction CSP3
0.45
Chiral centers
3.0
Largest ring
6.0
QED
0.69
Structural alerts
2
aggregator (Aggregator Advisor)
Aggregators
aggregator (ZINC)
Aggregators
Related compounds
Custom attributes
(extracted from source data)
Selectivity
HSV1
Pathway
Microbiology/virology
Anti-infection
Member status
member
MOA
"Heat Shock Protein 27 (hsp27) Inhibitors
Reverse Transcriptase Inhibitors"
Heat Shock Protein 27 (hsp27) Inhibitors
Reverse Transcriptase Inhibitors
DNA directed DNA polymerase inhibitor
Indication
shingles
Target
CMV
HSV-1
VZV
Source data