General
Preferred name
CARMUSTINE
Synonyms
bis-chloroethylnitrosourea ()
Nitrumon ()
Gliadel ()
BCNU ()
BiCNU ()
Carmubris ()
bis-chloroethylnitrosourea, BCNU, BiCNU| ()
DTI-015 ()
carmustine implant, Shandong Lanjin ()
CarmustineBi CNUBCNUBis(chloroethyl)nitrosourea1,3-Bis(2-chloroethyl)nitrosoureaN,N'-Bis(2-chloroethyl)-N-nitrosoureaNitrumonCarmustinCarmubrisBis(2-chloroethyl)nitrosourea ()
bis-chloroethylnitrosourea, BCNU, BiCNU ()
Bischloroethyl nitrosourea ()
NSC-409962 ()
Carmustine medac (previously carmustine obvius) ()
Carmustina ()
FDA-0345 ()
SRI-1720 ()
SK-27702 ()
Camustine ()
Becenun ()
Carmustine obvius ()
P&D ID
PD002792
CAS
154-93-8
Tags
available
drug
Approved by
FDA
First approval
1977
Drug indication
Liver cancer
Brain cancer
Astrocytoma
Drug Status
investigational
approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Carmustine is an antitumor chemotherapeutic agent, which works by akylating DNA and RNA.
PRICE 29
DESCRIPTION A glutathione reductase inhibitor, DNA/RNA inhibitor. (GtoPdb)
DESCRIPTION DNA alkylating agent; causes interstrand crosslinks (LOPAC library)
DESCRIPTION Carmustine (bis-chloroethylnitrosourea) is a cell-cycle phase nonspecific alkylating antineoplastic agent. (TargetMol Bioactive Compound Library)
Cell lines
29
Organisms
0
Compound Sets
26
Cayman Chemical Bioactives
15775
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL513
ChEMBL Drugs
CHEMBL513
CZ-OPENSCREEN Bioactive Library
DrugBank
DB00262
DrugBank Approved Drugs
DB00262
DrugCentral
512
DrugCentral Approved Drugs
512
DrugMAP
DMXZRW0
DrugMAP Approved Drugs
DMXZRW0
DrugMatrix
Enamine BioReference Compounds
Guide to Pharmacology
6800
JUMP-MOA Compound Set
2578
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL513
MedChem Express Bioactive Compound Library
HY-13585
NCATS Inxight Approved Drugs
U68WG3173Y
NIH Approved Oncology Drugs
479311
NPC Screening Collection
Nuisance compounds in cellular assays
ReFrame library
Selleckchem Bioactive Compound Library
carmustine
TargetMol Bioactive Compound Library
T3091
The Spectrum Collection
External IDs
271
Properties
(calculated by RDKit )
Molecular Weight
213.01
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
5
Ring Count
0
Aromatic Ring Count
0
cLogP
1.16
TPSA
61.77
Fraction CSP3
0.8
Chiral centers
0.0
Largest ring
0.0
QED
0.42
Structural alerts
1
Genotoxic
Nuisance compounds
Custom attributes
(extracted from source data)
MOA
DNA alkylator
DNA Alkylator/Crosslinker
DNA inhibitor
Target
Glutathione reductase
DNA
RNA
DNA alkylator/crosslinker
DNA/RNA Synthesis
Pathway
Cell Cycle/DNA Damage
DNA Damage/DNA Repair
Source data