General
Preferred name
CORTICOSTERONE
Synonyms
11¦Â,21-dihydroxyprogesterone ()
Corticosterone (From plants) ()
Kendall's compound B ()
11β,21-Dihydroxyprogesterone ()
17-deoxycortisol ()
17-deoxycortisol, 11β,21-dihydroxyprogesterone ()
11??21-Dihydroxyprogesterone ()
17-deoxycortisol, 11??21-dihydroxyprogesterone ()
(11-BETA)-11,21-DIHYDROXY-PREGN-4-ENE-3,20-DIONE ()
17-deoxycortisol, 11¦Â,21-dihydroxyprogesterone ()
Corticosterone (NSC-9705) ()
Preg-4-ene-3,20-dione,11-b,21-dihydroxy- ()
11-b,21-Dihydroxypregn-3,20-dione ()
Reichstein's substance h ()
NSC-9705 ()
Corticosterone-d8 ()
[3H] corticosterone ()
P&D ID
PD002785
CAS
50-22-6
1271728-07-4
Tags
available
drug candidate
Drug indication
Discovery agent
osteoarthritis, hip
Drug Status
experimental
investigational
Max Phase
3.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Endogenous glucocorticoid.
(GtoPdb)
DESCRIPTION
Corticosterone (17-Deoxycortisol) is an orally active and adrenal cortex-produced glucocorticoid, which plays an important role in regulating neuronal functions of the limbic system (including hippocampus, prefrontal cortex, and amygdala). Corticosterone increases the Rab-mediated AMPAR membrane traffic via SGK-induced phosphorylation of GDI. Corticosterone also interferes with the maturation of dendritic cells and shows a good immunosuppressive effect[1][2][3][4].
PRICE
29
DESCRIPTION
[3H] corticosterone is a tritiated version of . It can be used as a radio-tracer to examine corticosterone's behaviour in biological experiments .
(GtoPdb)
DESCRIPTION
Potent antiestrogen; ERalpha ligand
(Tocris Bioactive Compound Library)
DESCRIPTION
Endogenous glucocorticoid
(Tocriscreen Plus)
DESCRIPTION
Glucocorticoid secreted by the adrenal cortex; activates both mineralcorticoid and glucocorticoid receptors
(LOPAC library)
DESCRIPTION
Corticosterone (Kendall's compound B) is an adrenocortical steroid with salocorticoid and glucocorticoid activity that is orally active. Corticosterone is involved in the regulation of energy, immune responses, and stress responses in the body.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
1
Compound Sets
21
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugMAP
EU-OPENSCREEN Bioactive Compound Library
LOPAC library
MedChem Express Bioactive Compound Library
NIH Clinical Collections (NCC)
NURSA ligand set
Prestwick Chemical Library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Plus
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
51
Molecular Weight
346.21
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
2
Ring Count
4
Aromatic Ring Count
0
cLogP
2.67
TPSA
74.6
Fraction CSP3
0.81
Chiral centers
7.0
Largest ring
6.0
QED
0.81
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Nuclear Receptors
Selectivity
Glucocorticoid
Target
Endogenous Metabolite
Glucocorticoid Receptor
HSD11B1, NCOA1, NR3C2
iGluR
Primary Target
Glucocorticoid Receptors
MOA
GR inhibitor
Agonist
mineralocorticoid receptor agonist
Pathway
Endocrinology/Hormones
Metabolism
Immunology/Inflammation
Membrane Transporter/Ion Channel
Metabolic Enzyme/Protease
Neuronal Signaling
Vitamin D Related/Nuclear Receptor
Source data
