General
Preferred name
CORTICOSTERONE
Synonyms
11¦Â,21-dihydroxyprogesterone ()
11??,21-Dihydroxyprogesterone ()
Kendall's compound B ()
17-deoxycortisol ()
17-deoxycortisol, 11β,21-dihydroxyprogesterone ()
11??21-Dihydroxyprogesterone ()
17-deoxycortisol, 11??21-dihydroxyprogesterone ()
(11-BETA)-11,21-DIHYDROXY-PREGN-4-ENE-3,20-DIONE ()
11β,21-Dihydroxyprogesterone ()
Corticosterone (NSC-9705) ()
17-deoxycortisol, 11¦Â,21-dihydroxyprogesterone ()
Preg-4-ene-3,20-dione,11-b,21-dihydroxy- ()
11-b,21-Dihydroxypregn-3,20-dione ()
Reichstein's substance h ()
NSC-9705 ()
Corticosteron ()
Corticosterone-d8 ()
P&D ID
PD002785
CAS
50-22-6
1271728-07-4
Tags
drug candidate
natural product
available
Drug indication
Discovery agent
Drug Status
experimental
investigational
Max Phase
Phase 3
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Endogenous glucocorticoid.
(GtoPdb)
DESCRIPTION
Glucocorticoid secreted by the adrenal cortex; activates both mineralcorticoid and glucocorticoid receptors
(LOPAC library)
DESCRIPTION
Endogenous glucocorticoid
(Tocriscreen Plus)
DESCRIPTION
Potent antiestrogen; ERalpha ligand
(Tocris Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
1
Compound Sets
20
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
DrugMAP
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
LOPAC library
MedChem Express Bioactive Compound Library
NIH Clinical Collections (NCC)
NURSA ligand set
Prestwick Chemical Library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Plus
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
45
Molecular Weight
346.21
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
2
Ring Count
4
Aromatic Ring Count
0
cLogP
2.67
TPSA
74.6
Fraction CSP3
0.81
Chiral centers
7.0
Largest ring
6.0
QED
0.81
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Nuclear Receptors
Selectivity
Glucocorticoid
Pathway
Metabolism
Immunology/Inflammation
Membrane Transporter/Ion Channel
Metabolic Enzyme/Protease
Neuronal Signaling
Vitamin D Related/Nuclear Receptor
Target
Glucocorticoid Receptor
HSD11B1, NCOA1, NR3C2
Endogenous Metabolite
iGluR
Primary Target
Glucocorticoid Receptors
MOA
GR inhibitor
Agonist
mineralocorticoid receptor agonist
Source data
