General
Preferred name
FENCLONINE
Synonyms
FENCLONINE (+/-) ()
Fencloninum ()
(±)-p-Chlorophenylalanine ()
Fenchlonine ()
PCPA ()
CP-10188 ()
4-Chloro-DL-phenylalanine ()
DL-4-Chlorophenylalanine ()
p-Chlorophenylalanine ()
Fenclonine (hydrochloride) ()
4-Chloro-DL-phenylalanine (hydrochloride) ()
PCPA (hydrochloride) ()
CP-10188 (hydrochloride) ()
Fenclonine, PCPA, CP-10188 ()
Fenclonina ()
NSC-77370 ()
P-chlorophenylalanine, dl- ()
CP-10,188 ()
p-chloro Phenylalanine ()
P&D ID
PD002772
CAS
7424-00-2
1991-78-2
14173-39-8
51274-82-9
23633-07-0
Tags
available
drug candidate
Drug indication
Discovery agent
Drug Status
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION A synthetic amino acid which covalently binds to tryptophan hydroxylase to cause depletion of serotonin in the brain . (GtoPdb)
PRICE 29
DESCRIPTION Cyclooxygenase-2 (COX-2) inhibitor (Tocris Bioactive Compound Library)
DESCRIPTION Depletes brain serotonin by irreversible inhibition of tryptophan hydroxylase. (LOPAC library)
DESCRIPTION Fenclonine is an irreversible tryptophan hydroxylase inhibitor, the rate-limiting enzyme in serotonin biosynthesis. (Enamine Bioactive Compounds)
DESCRIPTION Fenclonine (CP-10188) is a selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). Fenclonine(CP-10188) acts pharmacologically to deplete endogenous levels of serotonin. (TargetMol Bioactive Compound Library)
Compound Sets
17
Cayman Chemical Bioactives
26168
ChEMBL Drugs
CHEMBL1256351
Concise Guide to Pharmacology 2017/18
5240
Concise Guide to Pharmacology 2019/20
5240
Concise Guide to Pharmacology 2021/22
5240
Concise Guide to Pharmacology 2023/24
5240
DrugMAP
DMUBO3E
DrugMatrix
Enamine Bioactive Compounds
EBC-44060
Guide to Pharmacology
5240
LOPAC library
MedChem Express Bioactive Compound Library
HY-W772850
HY-B1368
NPC Screening Collection
Selleckchem Bioactive Compound Library
4-chloro-dl-phenylalanine
TargetMol Bioactive Compound Library
T1447
The Spectrum Collection
Tocris Bioactive Compound Library
0938
External IDs
45
Properties
(calculated by RDKit )
Molecular Weight
199.04
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
3
Ring Count
1
Aromatic Ring Count
1
cLogP
1.29
TPSA
63.32
Fraction CSP3
0.22
Chiral centers
1.0
Largest ring
6.0
QED
0.77
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
Tryptophan hydroxylase
Primary Target
Hydroxylases
MOA
Inhibitor
Pathway
Metabolism
Metabolic Enzyme/Protease
Target
hydroxylase
Source data