General
Preferred name
GANCICLOVIR
Synonyms
GANCICLOVIR HYDRATE ()
2'-Nor-2'-deoxyguanosine ()
BW 759 ()
RS-21592 ()
DHPG ()
Ganciclovir (sodium) ()
GANCICLOVIR SODIUM ()
BW 759 (sodium) ()
2'-Nor-2'-deoxyguanosine (sodium) ()
Ganciclovir (BW 759) ()
RS-21592, BW-759, 2'-Nor-2'-deoxyguanosine ()
RS-21592 sodium, Cytovene IV sodium, BW 759 sodium, 2'-Nor-2'-deoxyguanosine sodium ()
BW 759U ()
Cytovene ()
Gancyclovir ()
BW-759U ()
NSC-759656 ()
Ganzyk-rtu ()
Vitrasert ()
Zirgan ()
Valganciclovir hydrochloride impurity a ()
Cymevene ()
Virgan ()
Ganciclovir ()
Ganciclovir sodium salt ()
Ganciclovir (as sodium) ()
Cytovene iv ()
RS-21592 Sodium ()
Ganciclovir-d5 ()
Ganciclovir (sodium salt) ()
P&D ID
PD002768
CAS
82410-32-0
106931-35-5
107910-75-8
1189966-73-1
Tags
prodrug
natural product
drug
available
Approved by
FDA
First approval
1989
Drug Status
investigational
approved
withdrawn
Drug indication
Virus infection
Antiviral
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Ganciclovir Sodium is a potent inhibitor of the Herpesvirus family including cytomegalovirus. It is an acyclovir analog. It is used to treat complications from AIDS-associated cytomegalovirus infections. It was developed by Roche and has been listed. (BOC Sciences Bioactive Compounds)
DESCRIPTION Pro-drug nucleoside analog; upon thymidine kinase expression,converted to a phosphorylated active analog and incorporated into DNA, causing death of the malignant dividing cell (LOPAC library)
Cell lines
8
Organisms
20
Compound Sets
29
AdooQ Bioactive Compound Library
A11645
Axon Medchem Screening Library
3241
BOC Sciences Bioactive Compounds
ganciclovir-sodium-cas-107910-75-8-item-81473
Cayman Chemical Bioactives
13853
37487
22565
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL182
CHEMBL1200850
ChEMBL Drugs
CHEMBL182
CHEMBL1200850
Drug Repurposing Hub
DrugBank
DB01004
DrugBank Approved Drugs
DB01004
DrugCentral
1277
DrugCentral Approved Drugs
1277
DrugMAP
DM1MBYQ
DrugMAP Approved Drugs
DM1MBYQ
DrugMatrix
Enamine BioReference Compounds
Ki Database
DHPG
LOPAC library
MedChem Express Bioactive Compound Library
HY-13637
HY-13637A
NCATS Inxight Approved Drugs
P9G3CKZ4P5
NIH Clinical Collections (NCC)
NPC Screening Collection
Pandemic Response Box
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
ganciclovir
ganciclovir-sodium
TargetMol Bioactive Compound Library
T0688
The Spectrum Collection
Withdrawn 2.0
EMA18
External IDs
83
Properties
(calculated by RDKit )
Molecular Weight
255.1
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
4
Rotatable Bonds
5
Ring Count
2
Aromatic Ring Count
2
cLogP
-1.97
TPSA
139.28
Fraction CSP3
0.44
Chiral centers
0.0
Largest ring
6.0
QED
0.49
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
G2-M checkpoint
MOA
viral DNA polymerase inhibitor
DNA polymerase inhibitor
Target
Human herpesvirus 1 DNA polymerase
FHV-1
Polymerase inhibitor
antibiotic
CMV
HSV
Nucleoside antimetabolite/analog
Pathway
Microbiology&virology
Anti-infection
Cell Cycle/DNA Damage
Indication
cytomegalovirus (CMV)
ATC
J05AB06
Therapeutic Class
Antiviral Agents
Solubility
10 mM in DMSO
Source data