General
Preferred name
GANCICLOVIR
Synonyms
GANCICLOVIR HYDRATE ()
RS-21592 sodium ()
Cytovene IV sodium ()
2'-Nor-2'-deoxyguanosine sodium ()
BW 759 sodium ()
BW 759 ()
RS-21592 ()
2'-Nor-2'-deoxyguanosine ()
DHPG ()
Ganciclovir (sodium) ()
BW 759 (sodium) ()
2'-Nor-2'-deoxyguanosine (sodium) ()
RS-21592, BW-759, 2'-Nor-2'-deoxyguanosine ()
RS-21592 sodium, Cytovene IV sodium, BW 759 sodium, 2'-Nor-2'-deoxyguanosine sodium ()
GANCICLOVIR SODIUM ()
Ganciclovir (BW 759) ()
Ganciclovir-d5 ()
Cymevene ()
Virgan ()
BW 759U ()
BW-759U ()
Ganzyk-rtu ()
Vitrasert ()
Vitrasert implant ()
NSC-759656 ()
Zirgan ()
Valganciclovir hydrochloride impurity a ()
Gancyclovir ()
Cytovene ()
Ganciclovir ()
RS-21592 Sodium ()
Ganciclovir sodium salt ()
Cytovene iv ()
Ganciclovir (as sodium) ()
Ganciclovir (sodium salt) ()
P&D ID
PD002768
CAS
82410-32-0
106931-35-5
107910-75-8
1189966-73-1
Tags
available
drug
prodrug
Approved by
FDA
First approval
1989
Drug indication
brain neoplasm
viral disease
Virus infection
Drug Status
approved
investigational
withdrawn
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Ganciclovir (BW 759), a nucleoside analogue, is an orally active antiviral agent with activity against CMV. Ganciclovir also has activity in vitro against members of the herpes group and some other DNA viruses. Ganciclovir inhibits the in vitro replication of human herpes viruses (HSV 1 and 2, CMV) and adenovirus serotypes 1, 2, 4, 6, 8, 10, 19, 22 and 28. Ganciclovir has an IC50 of 5.2 ¦ÌM for feline herpesvirus type-1 (FHV-1) and can diffuse into the brain[1][2][3].
PRICE 29
DESCRIPTION Ganciclovir (BW 759) sodium, a nucleoside analogue, is an orally active antiviral agent with activity against CMV. Ganciclovir sodium also has activity in vitro against members of the herpes group and some other DNA viruses. Ganciclovir sodium inhibits the in vitro replication of human herpes viruses (HSV 1 and 2, CMV) and adenovirus serotypes 1, 2, 4, 6, 8, 10, 19, 22 and 28. Ganciclovir sodium has an IC50 of 5.2 ¦ÌM for feline herpesvirus type-1 (FHV-1) and can diffuse into the brain[1][2][3].
PRICE 29
DESCRIPTION Pro-drug nucleoside analog; upon thymidine kinase expression,converted to a phosphorylated active analog and incorporated into DNA, causing death of the malignant dividing cell (LOPAC library)
DESCRIPTION Ganciclovir is a synthetic analog of 2'-deoxy-guanosine which is used to treat or prevent cytomegalovirus infections. It is is a DNA polymerase inhibitor. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections. (Enamine Bioactive Compounds)
DESCRIPTION Ganciclovir (2'-Nor-2'-deoxyguanosine) is an ACYCLOVIR analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections. (TargetMol Bioactive Compound Library)
DESCRIPTION Ganciclovir Sodium is a potent inhibitor of the Herpesvirus family including cytomegalovirus. It is an acyclovir analog. It is used to treat complications from AIDS-associated cytomegalovirus infections. It was developed by Roche and has been listed. (BOC Sciences Bioactive Compounds)
DESCRIPTION Ganciclovir sodium (Cytovene IV sodium) is the sodium salt of Ganciclovir with antiviral activity, especially against cytomegalovirus (CMV) and herpes simplex virus type 1 (HSV-1). (TargetMol Bioactive Compound Library)
Cell lines
8
Organisms
17
Compound Sets
31
AdooQ Bioactive Compound Library
A11645
Axon Medchem Screening Library
3241
BOC Sciences Bioactive Compounds
ganciclovir-sodium-cas-107910-75-8-item-81473
Cayman Chemical Bioactives
13853
37487
22565
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL182
CHEMBL1200850
ChEMBL Drugs
CHEMBL182
CHEMBL1200850
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB01004
DrugBank Approved Drugs
DB01004
DrugCentral
1277
DrugCentral Approved Drugs
1277
DrugMAP
DM1MBYQ
DrugMAP Approved Drugs
DM1MBYQ
DrugMatrix
Enamine Bioactive Compounds
EBC-07889
Enamine BioReference Compounds
Ki Database
DHPG
LOPAC library
MedChem Express Bioactive Compound Library
HY-13637
HY-13637A
NCATS Inxight Approved Drugs
P9G3CKZ4P5
NIH Clinical Collections (NCC)
NPC Screening Collection
Pandemic Response Box
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
ganciclovir
ganciclovir-sodium
TargetMol Bioactive Compound Library
T0688
T22337
The Spectrum Collection
Withdrawn 2.0
EMA18
External IDs
96
Properties
(calculated by RDKit )
Molecular Weight
255.1
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
4
Rotatable Bonds
5
Ring Count
2
Aromatic Ring Count
2
cLogP
-1.97
TPSA
139.28
Fraction CSP3
0.44
Chiral centers
0.0
Largest ring
6.0
QED
0.49
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
G2-M checkpoint
MOA
viral DNA polymerase inhibitor
DNA polymerase inhibitor
Target
Human herpesvirus 1 DNA polymerase
Polymerase inhibitor
antibiotic
CMV
HSV
Nucleoside antimetabolite/analog
Feline herpesvirus type-1(FHV-1)
HSV-1
FHV-1
Pathway
Cell Cycle/Checkpoint
DNA Damage/DNA Repair
Microbiology/virology
Anti-infection
Cell Cycle/DNA Damage
Indication
cytomegalovirus (CMV)
ATC
J05AB06
Therapeutic Class
Antiviral Agents
Solubility
10 mM in DMSO
Source data