General
Preferred name
FLECAINIDE ACETATE
Synonyms
Flecainide (acetate) ()
R-818 ()
Flecainide monoacetate ()
Tambocor ()
P&D ID
PD002766
CAS
54143-56-5
Tags
drug
available
Drug Status
approved
Max Phase
4.0
Drug indication
Atrial fibrillation
First approval
1985
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Flecainide acetate (R-818) is a class 1C antiarrhythmic agent especially used for the management of supraventricular arrhythmia; works by blocking the Nav1.5 sodium channel in the heart, causing prolongation of the cardiac action potential.
PRICE 40
DESCRIPTION Sodium channel blocker; Class I antiarrythmic agent (LOPAC library)
DESCRIPTION Cardiac Na+ channel blocker. Antiarrhythmic (Tocriscreen Plus)
DESCRIPTION Cardiac Na+ channel blocker. Antiarrhythmic (Tocriscreen Total)
DESCRIPTION Flecainide acetate (R-818) is a class Ic antiarrhythmic agent used to prevent and treat tachyarrhythmias (abnormally fast heart rhythms). (TargetMol Bioactive Compound Library)
DESCRIPTION GABA-mimetic; selectively interacts with beta2- and beta3-subunit containing GABAA receptors (Tocris Bioactive Compound Library)
Cell lines
0
Organisms
1
Compound Sets
12
Cayman Chemical Bioactives
20388
ChEMBL Approved Drugs
CHEMBL1200822
ChEMBL Drugs
CHEMBL1200822
LOPAC library
MedChem Express Bioactive Compound Library
HY-17429
NIH Clinical Collections (NCC)
Prestwick Chemical Library
TargetMol Bioactive Compound Library
T7219
The Spectrum Collection
Tocris Bioactive Compound Library
1470
Tocriscreen Plus
1470
Tocriscreen Total
External IDs
21
Properties
(calculated by RDKit )
Molecular Weight
474.16
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
3
Rotatable Bonds
7
Ring Count
2
Aromatic Ring Count
1
cLogP
3.53
TPSA
96.89
Fraction CSP3
0.58
Chiral centers
1.0
Largest ring
6.0
QED
0.52
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Ion Channels
Target
Nav1.5 channel
Sodium Channel
Primary Target
Voltage-gated Sodium (NaV) Channels
MOA
Blocker
Pathway
Membrane Transporter/Ion Channel
Source data