General
Preferred name
HYDROXYPROGESTERONE
Synonyms
17alpha-hydroxyprogesterone ()
17-OHP ()
17-Hydroxyprogesterone ()
17¦Á-Hydroxyprogesterone ()
17α-Hydroxyprogesterone ()
Gestageno ()
17α-hydroxyprogesterone ()
Hydroxyprogesterone ()
17?-Hydroxyprogesterone ()
17??-Hydroxyprogesterone ()
P&D ID
PD002763
CAS
68-96-2
Tags
available
drug
Drug indication
Solid tumour/cancer
Drug Status
approved
experimental
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION 17¦Á-Hydroxyprogesterone is a steroid hormone. 17¦Á-Hydroxyprogesterone induces ovarian growth and yolk production in female crabs and increases blood pressure in sheep. 17¦Á-Hydroxyprogesterone is mainly used in research related to crustacean reproduction and animal hypertension[1][2].
PRICE 29
DESCRIPTION 17??-Hydroxyprogesterone (17-OHP) is a physiological progestin that is produced during glucocorticoid and steroid hormone synthesis and is increased during the third trimester of pregnancy. Hydroxyprogesterone binds to the cytoplasmic progesterone receptors in the reproductive system and subsequently activates progesterone receptor-mediated gene expression.
DESCRIPTION Metabolite of progesterone (LOPAC library)
DESCRIPTION 17α-Hydroxyprogesterone (17-OHP) is a physiological progestin that is produced during glucocorticoid and steroid hormone synthesis and is increased during the third trimester of pregnancy. Hydroxyprogesterone binds to the cytoplasmic progesterone receptors in the reproductive system and subsequently activates progesterone receptor-mediated gene expression. (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
2
Compound Sets
13
Cayman Chemical Bioactives
33154
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB14570
DrugMAP
DMIKQH5
DrugMAP Approved Drugs
DMIKQH5
Guide to Pharmacology
5104
LOPAC library
MedChem Express Bioactive Compound Library
HY-B0891
NCATS Inxight Approved Drugs
21807M87J2
NPC Screening Collection
Selleckchem Bioactive Compound Library
17-hydroxyprogesterone
TargetMol Bioactive Compound Library
T1429
External IDs
52
Properties
(calculated by RDKit )
Molecular Weight
330.22
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
1
Ring Count
4
Aromatic Ring Count
0
cLogP
3.84
TPSA
54.37
Fraction CSP3
0.81
Chiral centers
6.0
Largest ring
6.0
QED
0.79
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
Progesterone
Target
Endogenous Metabolite
ER
Progesterone Receptor
PGR
Estrogen/progestogen Receptor
Indication
spontaneous preterm birth
MOA
Progesterone receptor agonist
Pathway
Endocrinology/Hormones
Metabolism
Metabolic Enzyme/Protease
Vitamin D Related/Nuclear Receptor
Source data