General
Preferred name
DISOPYRAMIDE
Synonyms
DISOPYRAMIDE PHOSPHATE ()
Triombrin ()
Hypaque sodium ()
amidotrizoate sodium ()
Disopyramide (phosphate) ()
Dicorantil ()
SC-7031 ()
Dicorantil (phosphate) ()
SC-7031 (phosphate) ()
CARBETAPENTANE CITRATE ()
Pentoxyverine Citrate ()
NSC-756744 ()
Rythmodan Ret ()
Norpace Cr ()
Isomide CR ()
SC-7031 PHOSPHATE ()
Rythmodan ()
Dirythmin sa ()
Dirythmin ()
Dirythmin-SA ()
Norpace ()
Diso-duriles ()
SC-13957 ()
Searle-703 ()
(rs)-disopyramide ()
Lispine ()
Rythmodan p ()
H-3292 ()
Isorythm ()
Disopiramida ()
Ritmilen ()
Dl-disopyramide ()
P&D ID
PD002749
CAS
22059-60-5
3737-09-5
1216989-88-6
23142-01-0
Tags
available
drug
Approved by
FDA
First approval
1977
Drug indication
Urinary incontinence
Atrial fibrillation
Ventricular arrhythmias
cardiac arrhythmia
Drug Status
approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Disopyramide phosphate is a class IA antiarrhythmic agent with efficacy in ventricular and atrial arrhythmias. Disopyramide phosphate blocks the fast inward sodium current of cardiac muscle and prolongs the duration of cardiac action potentials. Disopyramide phosphate inhibits HERG encoded potassium channels. Disopyramide phosphate also exhibits complex protein binding, and has a potent negative inotropic action[1][2][3].
DESCRIPTION Marketed formulations may containdisopyramide phosphate (PubChem CID 30928). (GtoPdb)
DESCRIPTION Disopyramide (Dicorantil) is a class IA antiarrhythmic agent with efficacy in ventricular and atrial arrhythmias. Disopyramide blocks the fast inward sodium current of cardiac muscle and prolongs the duration of cardiac action potentials. Disopyramide inhibits HERG encoded potassium channels. Disopyramide also exhibits complex protein binding, and has a potent negative inotropic action[1][2][3].
PRICE 29
DESCRIPTION K+ channel modulator; anti-arrhythmic; cardiac depressant (LOPAC library)
DESCRIPTION Disopyramide is a sodium channel blocker that, in rabbit ventricular myocytes, binds and dissociates from open channels more quickly than from resting channels. Formulations containing disopyramide have been used in the treatment of cardiac arrhythmias and hypertrophic cardiomyopathy. (BOC Sciences Bioactive Compounds)
DESCRIPTION Sodium channel blocker; class IA antiarrhythmic (LOPAC library)
DESCRIPTION Disopyramide is a Type 1A antiarrhythmic drug. It inhibits the fast sodium channels. It has a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties. Disopyramide is used for the treatment of documented ventricular arrhythmias, such as sustained ventricular tachycardia, ventricular pre-excitation and cardiac dysrhythmias. (Enamine Bioactive Compounds)
DESCRIPTION Disopyramide (Triombrin) is a class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties. (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
3
Compound Sets
31
BOC Sciences Bioactive Compounds
disopyramide-free-base-cas-3737-09-5-item-67415
Cayman Chemical Bioactives
23227
ChEMBL Approved Drugs
CHEMBL1201020
CHEMBL517
ChEMBL Drugs
CHEMBL1201020
CHEMBL517
Concise Guide to Pharmacology 2017/18
7167
Concise Guide to Pharmacology 2019/20
7167
Concise Guide to Pharmacology 2021/22
7167
Concise Guide to Pharmacology 2023/24
7167
Drug Repurposing Hub
DrugBank
DB00280
DrugBank Approved Drugs
DB00280
DrugCentral
926
DrugCentral Approved Drugs
926
DrugMAP
DM5SYZP
DrugMAP Approved Drugs
DM5SYZP
DrugMatrix
Enamine Bioactive Compounds
EBC-12812
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS102301
Guide to Pharmacology
7167
LOPAC library
MedChem Express Bioactive Compound Library
HY-12533A
HY-12533
NCATS Inxight Approved Drugs
GFO928U8MQ
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
disopyramide-phosphate
pentoxyverine-carbetapentane-citrate
disopyramide
TargetMol Bioactive Compound Library
T1320
The Spectrum Collection
External IDs
57
Properties
(calculated by RDKit )
Molecular Weight
339.23
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
8
Ring Count
2
Aromatic Ring Count
2
cLogP
3.36
TPSA
59.22
Fraction CSP3
0.43
Chiral centers
1.0
Largest ring
6.0
QED
0.8
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
mAChR
Potassium Channel
Sodium Channel
CHRM1, CHRM2, CHRM3, KCND2, KCND3, KCNH2, SCN5A
AChR
MOA
AChR antagonist
Potassium Channel inhibitor
Sodium Channel inhibitor
Antiarrhythmic agent
Sodium Channel blocker
Member status
member
Indication
ventricular tachycardia (VT), ventricular arrhythmias
Pathway
Membrane Transporter/Ion Channel
Neuroscience
Therapeutic Class
Antiarrhythmic Agents
Source data