General
Preferred name
DAHP
Synonyms
2,4-Diaminohypoxanthine ()
2,4-Diamino-6-pyrimidinone ()
2,4-Diamino-6-hydroxypyrimidine ()
P&D ID
PD002746
CAS
56-06-4
40306-60-3
Tags
natural product
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Inhibitor of GTP cyclohydrolase I, the rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis; blocks the induction of nitric oxide synthesis (LOPAC library)
DESCRIPTION 2,4-Diamino-6-hydroxypyrimidine has been found to be a GCH1 inhibitor and could suppress the activity of NO synthase through preventing the synthesis of BH4. (BOC Sciences Bioactive Compounds)
Compound Sets
8
BOC Sciences Bioactive Compounds
2-4-diamino-6-hydroxypyrimidine-cas-56-06-4-148713
Cayman Chemical Bioactives
81260
DrugMatrix
LOPAC library
MedChem Express Bioactive Compound Library
HY-100954
NPC Screening Collection
Selleckchem Bioactive Compound Library
2-4-diamino-6-hydroxypyrimidine
TargetMol Bioactive Compound Library
T7461
External IDs
32
Properties
(calculated by RDKit )
Molecular Weight
126.05
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
3
Rotatable Bonds
0
Ring Count
1
Aromatic Ring Count
1
cLogP
-0.65
TPSA
98.05
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.43
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Selectivity
GTP cyclohydrolase I
Pathway
Immunology/Inflammation
Metabolism
NF-??b
Target
NO Synthase
GTPCH
Source data