General
Preferred name
NEFIRACETAM
Synonyms
DZL-221 ()
DM9384 ()
Nefiracetam (Translon) ()
DZL 221 ()
NSC-759830 ()
P&D ID
PD002742
CAS
77191-36-7
Tags
natural product
drug
available
Drug Status
investigational
approved
Max Phase
Phase 2
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Pyrrolidonetype nootropic agent with various pharmacologic as well as cognition-enhancing effects.
(LOPAC library)
DESCRIPTION
Cognitive enhancer
(Tocriscreen Plus)
DESCRIPTION
KV7 channel activator; also GABAA modulator and indirect NMDA antagonist
(Tocris Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
18
AdooQ Bioactive Compound Library
Cayman Chemical Bioactives
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugCentral
DrugCentral Approved Drugs
DrugMatrix
Enamine BioReference Compounds
LOPAC library
MedChem Express Bioactive Compound Library
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
Tocris Bioactive Compound Library
Tocriscreen Plus
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
26
Molecular Weight
246.14
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
3
Ring Count
2
Aromatic Ring Count
1
cLogP
1.86
TPSA
49.41
Fraction CSP3
0.43
Chiral centers
0.0
Largest ring
6.0
QED
0.88
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Ion Channels
Pathway
Membrane Transporter/Ion Channel
Neuroscience
Neuronal Signaling
Target
GABAR
CHRM1
GABA Receptor
Primary Target
Other Acetylcholine
MOA
acetylcholine receptor agonist, benzodiazepine receptor agonist
Source data
