General
Preferred name
FGIN-1-27
Synonyms
N,N-Dihexyl-2-(4-fluorophenyl)indole-3-acetamide ()
FGIN 1-27 ()
FGIN 1 27 ()
P&D ID
PD002740
CAS
142720-24-9
Tags
available
drug candidate
Drug indication
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
FGIN 1-27, an indoleacetamide, is a specific peripheral benzodiazepine receptor (PBR) ligand with a Ki of 5.0 nM. FGIN 1-27 can penetrate the blood brain barrier (BBB). FGIN 1-27 inhibits the onset of Isoniazid-induced convulsions[1].
PRICE
57
DESCRIPTION
activator of peripheral benzodiazepine receptor/translocator protein
(Informer Set)
DESCRIPTION
Potent, specific ligand for mitochondrial DBI receptor
(Tocriscreen Plus)
DESCRIPTION
High affinity ligand for glial mitochondrial benzodiazepine receptors
(LOPAC library)
DESCRIPTION
Potent, specific ligand for mitochondrial DBI receptor
(Tocriscreen Total)
DESCRIPTION
FGIN-1-27 is a high affinity agonist of mitochondrial benzodiazepine receptors (PBR) binding to benzodiazepine receptors on mitochondrial membranes. FGIN-1-27 indirectly potentiates GABAA receptor signaling to exhibit anticonvulsant, anxiolytic, and sedative activity in both animal and clinical models.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Antagonist at peripheral benzodiazepine receptors
(Tocris Bioactive Compound Library)
DESCRIPTION
FGIN-1-27 is a high-affinity agonist of the translocator protein and a specific peripheral benzodiazepine receptor (PBR) ligand(Ki = 5.0 nM). FGIN 1-27 can cross the blood-brain barrier.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
14
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugMAP
DrugMatrix
Informer Set
LOPAC library
MedChem Express Bioactive Compound Library
ReFrame library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Plus
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
21
Molecular Weight
436.29
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
1
Rotatable Bonds
13
Ring Count
3
Aromatic Ring Count
3
cLogP
7.51
TPSA
36.1
Fraction CSP3
0.46
Chiral centers
0.0
Largest ring
6.0
QED
0.28
Structural alerts
2
aggregator (Aggregator Advisor)
Aggregators
aggregator (ZINC)
Aggregators
Related compounds
Custom attributes
(extracted from source data)
Target
TSPO
peripheral benzodiazepine receptor (PBR)
GABA Receptor
Compound status
probe
Target Type
Ion Channels
Selectivity
Mitochondria
Primary Target
Translocator Protein
MOA
inositol monophosphatase inhibitor
Pathway
Membrane Transporter/Ion Channel
Neuronal Signaling
Source data
