General
Preferred name
FEXOFENADINE
Synonyms
FEXOFENADINE HYDROCHLORIDE ()
Fexofenadine D6 ()
MDL-16455 D6 ()
MDL-16455 hydrochloride ()
Terfenidine carboxylate hydrochloride ()
Telfast ()
Terfenadine carboxylate D6 ()
Fexofenadine HCl ()
Fexofenadine (hydrochloride) ()
MDL-16455 (hydrochloride) ()
Terfenadine carboxylate (hydrochloride) ()
MDL 16455A ()
MDL 16,455A ()
MDL-16455A ()
Allegra Hives ()
Children's fexofenadine hydrochloride allergy ()
Children's fexofenadine hydrochloride hives ()
Fexofenadine Hydrochloride Allergy ()
Children's allegra allergy ()
Allegra Allergy ()
Allegra ()
Children's allegra hives ()
Telfast 30 ()
Telfast 180 ()
Telfast 120 ()
Fexofenadine Hydrochloride Hives ()
Fexofenadine-d10 (hydrochloride) ()
P&D ID
PD002734
CAS
153439-40-8
159389-12-5
83799-24-0
1319714-86-7
138452-21-8
1215821-44-5
Tags
probe
natural product
drug
available
Approved by
FDA
First approval
1996
Drug Status
investigational
approved
Drug indication
Allergic rhinitis
Antihistaminic
Max Phase
Phase 4
Probe info
Probe type
calculated probe
Probe sources
Probe Miner (suitable probes)
Probe targets
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Fexofenadine is an antihistamine (histamine H1 receptor antagonist), non-sedating antiallergic agent. The approved drug is a racemic mixture of two enatiomers (CID 9870655) and (CID 6603853). The structure shown here does not specify stereochemistry and represents the mixture.
MOA Like other H1-blockers, Fexofenadine competes with free histamine for binding at H1-receptors in the GI tract, large blood vessels, and bronchial smooth muscle. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms (eg. nasal congestion, watery eyes) brought on by histamine. Conversely, fexofenadine does not demonstrate any anticholinergic, antidopaminergic, alpha-1 adrenergic, or beta-adrenergic-receptor blocking activity.
DESCRIPTION Fexofenadine is a metabolite of . Fexofenadine is an antihistamine (histamine H1 receptor antagonist), non-sedating antiallergic agent. The approved drug is a racemic mixture of two enatiomers (CID 9870655) and (CID 6603853). The structure shown here does not specify stereochemistry and represents the mixture. (GtoPdb)
DESCRIPTION Selective sst4 agonist (Tocris Bioactive Compound Library)
DESCRIPTION H1 receptor antagonist; non-sedating antiallergic agent (Tocriscreen Plus)
DESCRIPTION H1 receptor antagonist; non-sedating antiallergic agent (Tocriscreen Total)
DESCRIPTION H1 Histamine receptor antagonist (LOPAC library)
DESCRIPTION Fexofenadine is Histamine H1 receptor antagonist. It can be used for the treatment of allergy symptoms, such as hay fever, nasal congestion, and urticaria. (BOC Sciences Bioactive Compounds)
Cell lines
0
Organisms
1
Compound Sets
39
AdooQ Bioactive Compound Library
A11859
Axon Medchem Screening Library
1453
BOC Sciences Bioactive Compounds
fexofenadine-cas-83799-24-0-354757
Cayman Chemical Bioactives
18191
26115
ChEMBL Approved Drugs
CHEMBL1200618
CHEMBL914
ChEMBL Drugs
CHEMBL1200618
CHEMBL914
Concise Guide to Pharmacology 2017/18
4819
Concise Guide to Pharmacology 2019/20
4819
Concise Guide to Pharmacology 2021/22
4819
Concise Guide to Pharmacology 2023/24
4819
DrugBank
DB00950
DrugBank Approved Drugs
DB00950
DrugCentral
1170
DrugCentral Approved Drugs
1170
DrugMAP
DM17ONX
DrugMAP Approved Drugs
DM17ONX
DrugMatrix
Enamine BioReference Compounds
EUbOPEN Chemogenomics Library
Guide to Pharmacology
4819
Ki Database
Fexofenadine
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL914
Mcule NIBR MoA Box Subset
MCULE-4193800017
MedChem Express Bioactive Compound Library
HY-B0801A
NCATS Inxight Approved Drugs
E6582LOH6V
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Other bioactive compounds
Prestwick Chemical Library
Probe Miner (suitable probes)
P35367/718016
ReFrame library
Selleckchem Bioactive Compound Library
fexofenadine-hcl
TargetMol Bioactive Compound Library
T1470L
The Spectrum Collection
Tocris Bioactive Compound Library
2429
Tocriscreen Plus
2429
Tocriscreen Total
External IDs
76
Properties
(calculated by RDKit )
Molecular Weight
501.29
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
3
Rotatable Bonds
10
Ring Count
4
Aromatic Ring Count
3
cLogP
5.51
TPSA
81.0
Fraction CSP3
0.41
Chiral centers
1.0
Largest ring
6.0
QED
0.34
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
7-TM Receptors
Selectivity
H1
Target
Histamine Receptor
H1 receptor
H1 antagonist
Pathway
Immunology/Inflammation
GPCR/G protein
Neuronal Signaling
Neuroscience
Primary Target
Histamine H1 Receptors
MOA
Antagonist
Histamine H1 Receptor Antagonists
Member status
member
Therapeutic Class
Antiallergic Agents
Solubility
Soluble in methanol.
Source data