General
Preferred name
MINOXIDIL
Synonyms
MINOXIDIL HYDROCHLORIDE ()
U10858 ()
Rogaine extra strength (for men) ()
Theroxidil ()
Women's rogaine ()
U-10,858 ()
Regaine For Men ()
Lonolox ()
Rogaine (for women) ()
Minoxidil (for men) ()
Rogaine ()
Minodyl ()
Loniten ()
Rogaine (for men) ()
Pierminox ()
Minoxidil extra strength (for men) ()
Men's Rogaine ()
Mintop ()
Alostil ()
Regaine For Women ()
NSC-757106 ()
Alopexil ()
Normoxidil ()
Tricoxidil ()
U-10858 ()
Minoximen ()
Minoxidil (for women) ()
Prexidil ()
Minoxidil-d10 ()
P&D ID
PD002726
CAS
38304-91-5
1020718-66-4
Tags
available
prodrug
drug
Approved by
FDA
First approval
1979
Drug Status
investigational
approved
Max Phase
Phase 4
Drug indication
Antihypertensive
Hair Growth Stimulant (topical)
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION The structure shown here is the same as the INN-assigned structure for this compound. The charges represent the movement of electrons towards the oxygen atom. Our representation of the structure is different to that shown on PubChem, where the molecule is shown without the charges. (GtoPdb)
DESCRIPTION Inhibits calcium-sensitive chloride currents (Tocris Bioactive Compound Library)
DESCRIPTION Kir6 channel (KATP) opener (Tocriscreen Plus)
DESCRIPTION K+ channel activator; antihypertensive (LOPAC library)
DESCRIPTION K+ channel (KATP) opener (Tocriscreen Total)
Compound Sets
27
Axon Medchem Screening Library
3490
Cayman Chemical Bioactives
15302
17563
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL802
ChEMBL Drugs
CHEMBL802
Concise Guide to Pharmacology 2017/18
4254
Concise Guide to Pharmacology 2019/20
4254
Concise Guide to Pharmacology 2021/22
4254
Concise Guide to Pharmacology 2023/24
4254
Drug Repurposing Hub
DrugBank
DB00350
DrugBank Approved Drugs
DB00350
DrugCentral
1814
DrugCentral Approved Drugs
1814
DrugMatrix
Enamine BioReference Compounds
Guide to Pharmacology
4254
LOPAC library
MedChem Express Bioactive Compound Library
HY-B0112
NCATS Inxight Approved Drugs
5965120SH1
NPC Screening Collection
Other bioactive compounds
ReFrame library
The Spectrum Collection
Tocris Bioactive Compound Library
0583
Tocriscreen Plus
0583
Tocriscreen Total
External IDs
50
Properties
(calculated by RDKit )
Molecular Weight
209.13
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
2
Rotatable Bonds
1
Ring Count
2
Aromatic Ring Count
1
cLogP
-0.13
TPSA
95.11
Fraction CSP3
0.56
Chiral centers
0.0
Largest ring
6.0
QED
0.5
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
ATP-sensitive inward rectifier potassium channel opener
Activator
KATP activator, Kir6 channel (KATP) activator, vasodilator
Target
Sulfonylurea receptor 2, Kir6.2
ABCC9, KCNJ1, KCNJ10, KCNJ11, KCNJ8, PTGS1
KATP channel opener
Endogenous Metabolite
Potassium Channel
Target Type
Ion Channels
Selectivity
ATP sensitive
Primary Target
Inward Rectifier Potassium (Kir) Channels
Indication
androgenetic alopecia
Pathway
Membrane Transporter/Ion Channel
Metabolic Enzyme/Protease
Source data