General
Preferred name
MIFEPRISTONE
Synonyms
RU486 ()
Mifepristone (Mifeprex) ()
RU48684371-65-3 ()
RU 38486 ()
RU486, C-1073, RU 38486, RU-486, Mifegyne ()
Mifepristone (RU486) ()
RU-486 ()
NSC-759862 ()
Mifepristona ()
Mifeprex ()
RU-38486 ()
RU 486 ()
Korlym ()
Mifegyne ()
Mifepristone-d3 ()
KORLYM ()
MIFEPREX ()
MIFEPRISTONA ()
P&D ID
PD002721
CAS
122742-25-0
83203-42-3
84371-65-3
Tags
available
drug
Approved by
FDA
First approval
2000
Drug indication
Cushing disease
cocaine dependence
Drug Status
approved
investigational
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
MOA The anti-progestational activity of mifepristone results from competitive interaction with progesterone at progesterone-receptor sites. Based on studies with various oral doses in several animal species (mouse, rat, rabbit and monkey), the compound inhibits the activity of endogenous or exogenous progesterone. The termination of pregnancy results.; ; In the treatment of Cushing's syndrome, Mifepristone blocks the binding of cortisol to its receptor. It does not decrease cortisol production but reduces the effects of excess cortisol, such as high blood sugar levels.
DESCRIPTION An antagonist of both the glucocorticoid receptor and the progesterone receptor. (GtoPdb)
DESCRIPTION Mifepristone (RU486) is a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist with IC50s of 0.2 nM and 2.6 nM in in vitro assay[1].
DESCRIPTION Highly potent ERbeta agonist (Tocris Bioactive Compound Library)
DESCRIPTION Progesterone and glucocorticoid receptor antagonist (Tocriscreen Plus)
DESCRIPTION Progesterone receptor antagonist (LOPAC library)
DESCRIPTION Progesterone and glucocorticoid antagonist (Tocriscreen Total)
DESCRIPTION Mifepristone is an antagonist of glucocorticoid, progesterone, and androgen receptors. Mifepristone have been used for the induction of medical abortions. (Enamine Bioactive Compounds)
Cell lines
2
Organisms
2
Compound Sets
38
AdooQ Bioactive Compound Library
A10591
Axon Medchem Screening Library
1502
Cayman Chemical Bioactives
10006317
10010660
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL1276308
ChEMBL Drugs
CHEMBL1276308
Concise Guide to Pharmacology 2017/18
2805
Concise Guide to Pharmacology 2019/20
2805
Concise Guide to Pharmacology 2021/22
2805
Concise Guide to Pharmacology 2023/24
2805
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB00834
DrugBank Approved Drugs
DB00834
DrugCentral
1805
DrugCentral Approved Drugs
1805
DrugMAP
DMGZQEF
DrugMAP Approved Drugs
DMGZQEF
Enamine Bioactive Compounds
EBC-06067
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS101471
EUbOPEN Chemogenomics Library
EUB0002157
Guide to Pharmacology
2805
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1276308
MedChem Express Bioactive Compound Library
HY-13683
NCATS Inxight Approved Drugs
320T6RNW1F
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
NURSA ligand set
nursa/index.jsf?doi=10.1621%2FST5A19ZOKW
Pandemic Response Box
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Mifepristone(Mifeprex)
Tocris Bioactive Compound Library
1479
Tocriscreen Plus
1479
Tocriscreen Total
External IDs
58
Properties
(calculated by RDKit )
Molecular Weight
429.27
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
2
Ring Count
5
Aromatic Ring Count
1
cLogP
5.41
TPSA
40.54
Fraction CSP3
0.55
Chiral centers
5.0
Largest ring
6.0
QED
0.64
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Nuclear Receptors
Selectivity
Progesterone
MOA
progesterone receptor antagonist
Glucocorticoid Receptor agonist
Antagonist
Androgen Receptor Ligands
Glucocorticoid Receptor (GR) Antagonists
Internal Ribosomal Entry Site (IRES) Inhibitors
Progesterone Receptor Antagonists
glucocorticoid receptor antagonist, progesterone receptor antagonist
Target
Glucocorticoid Receptor
Progesterone Receptor
AR, NR1I2, NR3C1, PGR
PR antagonist
Autophagy
Endogenous Metabolite
NO Synthase
Apoptosis related,Autophagy,Bcl-2,Estrogen/progestogen Receptor,Glucocorticoid Receptor
Primary Target
Progesterone Receptors
Member status
member
Indication
hyperglycemia, diabetes mellitus
Pathway
Immunology/Inflammation
Metabolic Enzyme/Protease
Vitamin D Related/Nuclear Receptor
Recommended Cell Concentration
None
Source data