General
Preferred name
estrone
Synonyms
Aquacrine ()
Oestrone ()
Fluoroethyl ()
E1 ()
Estrone-d2 ()
Follicular-hormone ()
1,3,5-estratrien-3-ol-17-one ()
Estrogenic Substance ()
Folliculinum ()
Natural estrogenic substance-estrone ()
Tokokin ()
Estrona ()
ketohydroxyestrin ()
Theelin ()
Estradiol metabolite e1 ()
Folliculin ()
Follicular hormone ()
NSC-9699 ()
WAY 164397 ()
Thelykinin ()
P&D ID
PD002719
CAS
53-16-7
37242-41-4
350820-16-5
Tags
available
drug
Approved by
FDA
First approval
1979
Drug indication
Obesity
Menopausal and postmenopausal disorder
Drug Status
approved
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Estrone, is an important endogenous mammalian estrogen, produced in vivo from androstenedione in the ovaries, placenta, and in adipose tissue. Post-menopausally, this is the primary circulating estrogen.
(GtoPdb)
DESCRIPTION
Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells[1][2].
PRICE
29
DESCRIPTION
Luteolytic estrogen produced by the corpus luteum
(LOPAC library)
DESCRIPTION
Estrone is an estrogenic hormone, one of the three naturally occurring estrogens (estrone, estradiol and estriol). Estrone is used for management of perimenopausal and postmenopausal symptoms.
(Enamine Bioactive Compounds)
DESCRIPTION
Estrone (Aquacrine) is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone, a major mammalian estrogen. It is converted from ANDROSTENEDIONE directly, or from TESTOSTERONE via ESTRADIOL. In humans, it is produced primarily by the cyclic ovaries, PLACENTA, and the ADIPOSE TISSUE of men and postmenopausal women.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
2
Compound Sets
29
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Enamine Bioactive Compounds
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
NPC Screening Collection
NURSA ligand set
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
58
Molecular Weight
270.16
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
0
Ring Count
4
Aromatic Ring Count
1
cLogP
3.82
TPSA
37.3
Fraction CSP3
0.61
Chiral centers
4.0
Largest ring
6.0
QED
0.78
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
Estrogen
Target
Endogenous Metabolite
ER
Estrogen Receptor/ERR
ESR1, ESR2
Estrogen/progestogen Receptor
MOA
estrogen receptor agonist, estrogenic hormone
Indication
menopause
Therapeutic Class
Antimenopausal Agents
Pathway
Endocrinology/Hormones
Metabolism
Metabolic Enzyme/Protease
Vitamin D Related/Nuclear Receptor
Source data
