General
Preferred name
FLUSPIRILENE
Synonyms
Redeptin ()
Fluspirilen ()
R 6218 ()
R-6218 ()
MCN-JR-6218 ()
Imap ()
P&D ID
PD002717
CAS
1841-19-6
Tags
available
probe
natural product
drug
Drug Status
investigational
approved
Drug indication
Antipsychotic
Schizophrenia
Max Phase
Phase 4
Probe info
Probe type
calculated probe
Probe sources
Probe targets
[[ compound.targets[t].gene_name ]]
Probe control
Probe control not defined
Orthogonal probes
2
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Fluspirilene is a long-acting typical antipsychotic drug.
(GtoPdb)
DESCRIPTION
Dopamine receptor antagonist; antipsychotic
(LOPAC library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
2
Compound Sets
21
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Guide to Pharmacology
Ki Database
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
Mcule NIBR MoA Box Subset
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
Probe Miner (suitable probes)
ReFrame library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
32
Molecular Weight
475.24
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
7
Ring Count
5
Aromatic Ring Count
3
cLogP
5.31
TPSA
35.58
Fraction CSP3
0.34
Chiral centers
0.0
Largest ring
6.0
QED
0.5
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
D2/D1
Member status
virtual
MOA
Dopamine D2 Antagonists
Dopamine Receptor antagonist
Target
CACNG1, DRD2, HRH1, HTR1A, HTR1D, HTR1E, HTR2A
Calcium Channel
Indication
schizophrenia
Therapeutic Class
Antipsychotic Agents
Pathway
Membrane Transporter/Ion Channel
Neuronal Signaling
Source data
