General
Preferred name
PHENSERINE
Synonyms
(-)-Phenserine ()
PHENSERINE TARTRATE ()
(-)-Eseroline phenylcarbamate ()
P&D ID
PD002716
CAS
109349-04-4
101246-66-6
156910-61-1
Tags
available
drug candidate
Drug indication
Alzheimer disease
Parkinson disease
Drug Status
investigational
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Selective, non-competitive acetylcholinesterase (AChE) inhibitor. (LOPAC library)
DESCRIPTION Phenserine, an analog of physostigmine, is an acetylcholinesterase (AChE) inhibitor (IC50= 24 nM) potentially for the treatment of Alzheimer Disease (AD). (BOC Sciences Bioactive Compounds)
Compound Sets
9
BOC Sciences Bioactive Compounds
phenserine-cas-101246-66-6-item-72546
Cayman Chemical Bioactives
21060
Drug Repurposing Hub
DrugBank
DB04892
DrugMAP
DMNCY1I
DMIGH6W
EU-OPENSCREEN Bioactive Compound Library
EOS102332
LOPAC library
MedChem Express Bioactive Compound Library
HY-103374
ReFrame library
External IDs
32
Properties
(calculated by RDKit )
Molecular Weight
337.18
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
2
Ring Count
4
Aromatic Ring Count
2
cLogP
3.67
TPSA
44.81
Fraction CSP3
0.35
Chiral centers
2.0
Largest ring
6.0
QED
0.91
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
Acetylcholinesterase
Target
Amyloid-¦Â
ACHE, BCHE
Amyloid-β
Cholinesterase (ChE)
MOA
acetylcholinesterase inhibitor, beta amyloid synthesis inhibitor
Pathway
Neuronal Signaling
Source data