General
Preferred name
HYDROCORTISONE
Synonyms
cortisol ()
Hydrocortisone base ()
Hydrocortisone(Cortisol) ()
Hydrocortisone (NSC 10483) ()
Eurax-Hydrocort ()
Acetasol HC ()
Cort-Dome ()
Cobadex ()
Texacort ()
Hydrocort In Wte Soft Paraf ()
Hc (hydrocortisone) ()
Otoseptil ()
Cipro HC ()
Penecort ()
H-Cort ()
Terra-Cortril ()
Mildison Lipocream ()
Daktacort Hydrocort ()
Anucort-Hc ()
Glycort ()
Quinocort ()
Evacort ()
Plenadren ()
Hydrocort In Cetomacrogol For A ()
Eldecort ()
Anusol Soothing Relief ()
Aeroseb-Hc ()
Dermacort ()
Hc #4 ()
Nybadex ()
Balneol-Hc ()
Perinal ()
Flexicort ()
Proctocream HC ()
Uniroid Hc ()
Exe-Cort ()
Topisone ()
Proctocort ()
Anflam ()
Acticort ()
Nystaform-HC ()
Sential HC ()
Dioderm ()
Micort-Hc ()
Calmurid HC ()
Efcortelan P ()
Medicort ()
Anugesic HC ()
Colocort ()
Germoloids HC ()
Gregoderm ()
Locoid ()
Canesten HC ()
Hydroderm HC ()
Neo-Cortef ()
Ophthocort ()
Cortenema ()
Nogenic hc ()
Stie-Cort ()
Eurax-Hc ()
Hydrocortisone In Absorbase ()
Alkindi sprinkle ()
Daktacort ()
Alphaderm ()
Cortef ()
Hydrocort In Calamine Oily ()
Nutracort ()
Tri-Cicatrin ()
Hydroderm ()
Cortril ()
Anusol Plus HC ()
Cortifoam ()
Timocort ()
Dome-Cort ()
Proctosedyl ()
Hi-Cor ()
Jungle For ()
Hc #1 ()
Anusol hc ()
Epicort ()
Hytone ()
Cortenem ()
Timodine ()
Synacort ()
Hydro-Rx ()
Hydrocortone ()
Terra-Cortril Nystatin ()
Xyloproct ()
Otosporin ()
Ala-Scalp ()
U-Cort ()
Zenoxone ()
Beta-Hc ()
NSC-10483 ()
Proctofoam HC ()
Econacort ()
Cor-Oticin ()
Derma Care Hydrocort ()
Dermaspray Demang ()
Corlan ()
Uniroid ()
Cetacort ()
Ala-Cort ()
Anusol-Hc ()
Hydrocortisone-d4 ()
P&D ID
PD002713
CAS
50-23-7
73565-87-4
Tags
natural product
drug
available
Approved by
EMA
FDA
First approval
1952
Drug Status
approved
vet_approved
Drug indication
Inflammation
Congenital adrenal hyperplasia
Glucocorticoid
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Cortisol is an endogenous adrenal glucocorticoid with immunosuppressant action. Approved as hydrocortisone. Hydrocortisone is a glucocorticoid receptor agonist.
Marketed formulations may contain hydrocortisone acetate (PubChem CID 5744). (GtoPdb)
DESCRIPTION Primary glucocorticoid secreted by the adrenal cortex (LOPAC library)
DESCRIPTION Adrenal glucocorticoid; immunosuppressant (Tocriscreen Plus)
DESCRIPTION Non-steroidal androgen receptor antagonist (Tocris Bioactive Compound Library)
Cell lines
1
Organisms
2
Compound Sets
30
AdooQ Bioactive Compound Library
A10457
Cayman Chemical Bioactives
20739
26500
ChEMBL Approved Drugs
CHEMBL389621
ChEMBL Drugs
CHEMBL389621
Concise Guide to Pharmacology 2017/18
2868
Concise Guide to Pharmacology 2019/20
2868
Concise Guide to Pharmacology 2021/22
2868
Concise Guide to Pharmacology 2023/24
2868
Drug Repurposing Hub
DrugBank
DB00741
DrugBank Approved Drugs
DB00741
DrugCentral
1388
DrugCentral Approved Drugs
1388
DrugMAP
DMGEMB7
DrugMAP Approved Drugs
DMGEMB7
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS101695
Guide to Pharmacology
2868
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL389621
MedChem Express Bioactive Compound Library
HY-N0583
NCATS Inxight Approved Drugs
WI4X0X7BPJ
NIH Clinical Collections (NCC)
NPC Screening Collection
NURSA ligand set
nursa/index.jsf?doi=10.1621%2FWQEMKA13C7
Prestwick Chemical Library
Selleckchem Bioactive Compound Library
Hydrocortisone
TargetMol Bioactive Compound Library
T1614
Tocris Bioactive Compound Library
4093
Tocriscreen Plus
4093
External IDs
96
Properties
(calculated by RDKit )
Molecular Weight
362.21
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
3
Rotatable Bonds
2
Ring Count
4
Aromatic Ring Count
0
cLogP
1.78
TPSA
94.83
Fraction CSP3
0.81
Chiral centers
7.0
Largest ring
6.0
QED
0.7
Structural alerts
2
aggregator (Aggregator Advisor)
Aggregators
aggregator (ZINC)
Aggregators
Related compounds
Custom attributes
(extracted from source data)
Target Type
Nuclear Receptors
Selectivity
Cortisol
Pathway
Metabolism
Immunology/Inflammation
Metabolic Enzyme/Protease
Vitamin D Related/Nuclear Receptor
Target
Glucocorticoid Receptor
ANXA1, NOS2, NR3C1, NR3C2
Endogenous Metabolite
Primary Target
Glucocorticoid Receptors
Disease Area
dermatology, neurology/psychiatry
Indication
eczema, psoriasis, seborrheic dermatitis, itching
MOA
Glucocorticoid Receptor agonist
Therapeutic Class
Antiinflammatory Agents
Source data