General
Preferred name
HYDROCORTISONE
Synonyms
cortisol ()
Hydrocortisone base ()
Hydrocortisone(Cortisol) ()
Hydrocortisone (NSC 10483) ()
Hidrocortisona ()
Cortenem ()
Proctocream HC ()
Efmody ()
Dermaspray Demang ()
Sential HC ()
Timocort ()
Texacort ()
Nogenic hc ()
Anugesic HC ()
Derma Care Hydrocort ()
Hydrocortisone component of acetasol hc ()
Germoloids HC ()
Hydrocortisone component of calmurid hc ()
Uniroid ()
Hydrocort In Calamine Oily ()
Eurax-Hc ()
Anusol Plus HC ()
Cortenema ()
Corlan ()
Flexicort ()
Nystaform-HC ()
Hydroderm ()
Alphaderm ()
Hydrocortisone component of pyocidin ()
Xyloproct ()
Hytone ()
Anucort-Hc ()
Epicort ()
Exe-Cort ()
Proctosedyl ()
Eurax-Hydrocort ()
Hydrocortisone component of pediotic ()
Nutracort ()
Jungle For ()
Hydrocortisone component of orlex hc ()
Hydrocortisone component of vosol hc ()
Dioderm ()
Hydrocort In Wte Soft Paraf ()
Hydrocortisone component of cortisporin ()
Proctofoam HC ()
Calmurid HC ()
Ala-Scalp ()
Econacort ()
Hi-Cor ()
Anusol-Hc ()
Hydro-Rx ()
Glycort ()
Quinocort ()
Cipro HC ()
Timodine ()
Cortril ()
Evacort ()
Colocort ()
Hydrocortisone component of achromycin ()
Dermacort ()
Zenoxone ()
Acticort ()
Anusol Soothing Relief ()
Daktacort Hydrocort ()
Cortef ()
Dome-Cort ()
NSC-10483 ()
Cort-Dome ()
Penecort ()
Alkindi sprinkle ()
Hc (hydrocortisone) ()
Synacort ()
Terra-Cortril Nystatin ()
Efcortelan P ()
Ala-Cort ()
Anflam ()
Hydrocortisone component of oticair ()
Hydrocortisone component of otobiotic ()
Eldecort ()
Hydrocortisone In Absorbase ()
Plenadren ()
Topisone ()
Canesten HC ()
Otosporin ()
Nybadex ()
Hydroderm HC ()
Cobadex ()
Balneol-Hc ()
Beta-Hc ()
Gregoderm ()
Otoseptil ()
H-Cort ()
Aeroseb-Hc ()
Hydrocort In Cetomacrogol For A ()
Cor-Oticin ()
Stie-Cort ()
Hydrocortone ()
Hc #1 ()
Acetasol HC ()
Uniroid Hc ()
Medicort ()
Ophthocort ()
Alkindi ()
Hydrocortisone component of alphaderm ()
Perinal ()
Hydrocortisone component of otocort ()
Anusol hc ()
Daktacort ()
Tri-Cicatrin ()
Proctocort ()
Cetacort ()
Hydrocortisone component of otobione ()
Mildison Lipocream ()
Hc #4 ()
U-Cort ()
Hydrocortisone component of xerese ()
[3H] cortisol ()
Hydrocortisone-d4 ()
P&D ID
PD002713
CAS
50-23-7
70094-60-9
73565-87-4
Tags
available
drug
endogenous
Approved by
FDA
EMA
First approval
1952
Drug indication
Heart failure
Congenital adrenal hyperplasia
Inflammation
Drug Status
investigational
vet_approved
approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Cortisol is an endogenous adrenal glucocorticoid with immunosuppressant action. Approved as hydrocortisone. Hydrocortisone is a glucocorticoid receptor agonist.
Marketed formulations may contain hydrocortisone acetate (PubChem CID 5744). (GtoPdb)
PRICE 29
DESCRIPTION Hydrocortisone (Cortisol) is a steroid hormone or glucocorticoid secreted by the adrenal cortex[1].
DESCRIPTION [3H] cortisol is a tritiated version of . It can be used as a radio-tracer to examine cortisol's behaviour in biological experiments . (GtoPdb)
DESCRIPTION Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. It is used to treat corticosteroid-responsive dermatoses, endocrine disorders, immune conditions, and allergic disorders. (Enamine Bioactive Compounds)
DESCRIPTION Non-steroidal androgen receptor antagonist (Tocris Bioactive Compound Library)
DESCRIPTION Adrenal glucocorticoid; immunosuppressant (Tocriscreen Plus)
DESCRIPTION Primary glucocorticoid secreted by the adrenal cortex (LOPAC library)
DESCRIPTION Hydrocortisone (Cortisol) is a glucocorticoid hormone secreted by the adrenocortex. Hydrocortisone agonizes the glucocorticoid receptor, which promotes proteolytic metabolism, gluconeogenesis, capillary wall stabilization, and renal calcium excretion, as well as suppressing immune and inflammatory responses. (TargetMol Bioactive Compound Library)
Cell lines
1
Organisms
2
Compound Sets
33
AdooQ Bioactive Compound Library
A10457
Cayman Chemical Bioactives
20739
26500
ChEMBL Approved Drugs
CHEMBL389621
ChEMBL Drugs
CHEMBL389621
Concise Guide to Pharmacology 2017/18
2868
Concise Guide to Pharmacology 2019/20
2868
Concise Guide to Pharmacology 2021/22
2868
Concise Guide to Pharmacology 2023/24
2868
Concise Guide to Pharmacology 2025/26
2868
13965
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB00741
DrugBank Approved Drugs
DB00741
DrugCentral
1388
DrugCentral Approved Drugs
1388
DrugMAP
DMGEMB7
DrugMAP Approved Drugs
DMGEMB7
Enamine Bioactive Compounds
EBC-11040
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS101695
Guide to Pharmacology
2868
13965
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL389621
MedChem Express Bioactive Compound Library
HY-N0583
NCATS Inxight Approved Drugs
WI4X0X7BPJ
NIH Clinical Collections (NCC)
NPC Screening Collection
NURSA ligand set
nursa/index.jsf?doi=10.1621%2FWQEMKA13C7
Prestwick Chemical Library
Selleckchem Bioactive Compound Library
Hydrocortisone
TargetMol Bioactive Compound Library
T1614
Tocris Bioactive Compound Library
4093
Tocriscreen Plus
4093
External IDs
435
Properties
(calculated by RDKit )
Molecular Weight
362.21
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
3
Rotatable Bonds
2
Ring Count
4
Aromatic Ring Count
0
cLogP
1.78
TPSA
94.83
Fraction CSP3
0.81
Chiral centers
7.0
Largest ring
6.0
QED
0.7
Structural alerts
2
aggregator (Aggregator Advisor)
Aggregators
aggregator (ZINC)
Aggregators
Related compounds
Custom attributes
(extracted from source data)
Target
Endogenous Metabolite
Environmental Pollutants
Glucocorticoid Receptor
ANXA1, NOS2, NR3C1, NR3C2
Target Type
Nuclear Receptors
Selectivity
Cortisol
Primary Target
Glucocorticoid Receptors
Disease Area
dermatology, neurology/psychiatry
Indication
eczema, psoriasis, seborrheic dermatitis, itching
MOA
Glucocorticoid Receptor agonist
Therapeutic Class
Antiinflammatory Agents
Pathway
Immunology/Inflammation
Metabolic Enzyme/Protease
Vitamin D Related/Nuclear Receptor
Endocrinology/Hormones
Metabolism
Source data