General
Preferred name
MNS
Synonyms
5-(2-Nitrovinyl)benzodioxole ()
NSC 170724 ()
3??4-Methylenedioxy-??-nitrostyrene ()
MDBN ()
Syk inhibitor III ()
MNS (3,4-Methylenedioxy-β-nitrostyrene) ()
MNS (3,4-Methylenedioxy-??nitrostyrene) ()
SBB007833 ()
3,4-methylenedioxy-beta-nitrostyrene ()
MNS (3,4-Methylenedioxy-??-nitrostyrene) ()
P&D ID
PD002712
CAS
1485-00-3
22568-48-5
Tags
available
covalent binder
drug candidate
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Src and Syk kinase inhibitor; prevents phosphorylation and cytoskeletal association of GPIIb/IIIa and talin. (LOPAC library)
DESCRIPTION MNS (3,4-methylenedioxy-beta-nitrostyrene) prevented platelet aggregation caused by various stimulators, and this action was accompanied by inhibition of tyrosine kinases. (BOC Sciences Bioactive Compounds)
Cell lines
2
Organisms
0
Compound Sets
12
BOC Sciences Bioactive Compounds
mns-cas-1485-00-3-362781
Cayman Chemical Bioactives
15206
CovalentInDB
CI006746
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugMAP
DMU8KGB
Enamine BioReference Compounds
Guide to Pharmacology
6048
LOPAC library
MedChem Express Bioactive Compound Library
HY-78263
Selleckchem Bioactive Compound Library
mdbn
TargetMol Bioactive Compound Library
T6594
External IDs
16
Properties
(calculated by RDKit )
Molecular Weight
193.04
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
0
Rotatable Bonds
2
Ring Count
2
Aromatic Ring Count
1
cLogP
1.66
TPSA
61.6
Fraction CSP3
0.11
Chiral centers
0.0
Largest ring
6.0
QED
0.53
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
Src/Syk
Pathway
Ubiquitination
Angiogenesis
Tyrosine Kinase/Adaptors
Protein Tyrosine Kinase/RTK
Target
p97, Syk, Src
SRC, SYK
SRC
SYK
p97,Src,Syk,Tyrosinase
MOA
SRC inhibitor, SYK inhibitor
Source data