General
Preferred name
IBUDILAST
Synonyms
AV-411 ()
MN-166 ()
KC-404 ()
Ibudilast (KC-404) ()
KC-404, AV411, MN166 ()
Ketas ()
AV411 ()
Ibudilast-d7 ()
P&D ID
PD002711
CAS
50847-11-5
050847-11-5
2713301-45-0
Tags
natural product
drug
available
Approved by
PMDA
First approval
1989
Drug indication
Alcohol dependence
Opioid dependence
Methamphetamine dependence
Amyotrophic lateral sclerosis
Castleman's disease
Multiple sclerosis
Drug Status
investigational
approved
Max Phase
Phase 3
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Ibudilast is a phosphodiesterase (PDE) inhibitor antiinflammatory drug. See the Biological activity tab for affinity data across a range of PDE isozymes.
(GtoPdb)
DESCRIPTION
PDE inhibitor (non-selective)
(Tocriscreen Plus)
DESCRIPTION
Phosphodiesterase IV (PDE IV) inhibitor
(LOPAC library)
DESCRIPTION
PDE inhibitor (non-selective)
(Tocriscreen Total)
DESCRIPTION
Cyclooxygenase inhibitor; may be selective for COX-3
(Tocris Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
30
AdooQ Bioactive Compound Library
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
JUMP-Target 1 Compound Set
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Plus
Tocriscreen Total
ZINC Tool Compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
37
Molecular Weight
230.14
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
0
Rotatable Bonds
3
Ring Count
2
Aromatic Ring Count
2
cLogP
3.3
TPSA
34.37
Fraction CSP3
0.43
Chiral centers
0.0
Largest ring
6.0
QED
0.76
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Enzymes
Selectivity
PDE IV
Pathway
Metabolism
Metabolic Enzyme/Protease
Target
PDE
IL1B, IL6, PDE3A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A
PDE4D
Phosphodiesterase (PDE)
Primary Target
Phosphodiesterases
MOA
Inhibitor
TLR4 (LPS) Receptor Antagonists
Leukotriene CysLT1 (LTD4) Antagonists
Phosphodiesterase Inhibitors
Mediator Release Inhibitors
leukotriene receptor antagonist, phosphodiesterase inhibitor
Member status
virtual
Indication
asthma, stroke
Disease Area
pulmonary, neurology/psychiatry
Source data
