General
Preferred name
L-165041
Synonyms
L-165,041 ()
{4-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy]phenoxy}acetic acid ()
L165,041 ()
P&D ID
PD002708
CAS
79558-09-1
242149-08-2
Tags
available
drug candidate
Drug indication
Discovery agent
Drug Status
experimental
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
L-165041 is a cell permeable PPAR¦Ä agonist, with Kis of 6 nM and appr 730 nM for PPAR¦Ä and PPAR¦Ã, respectively, and induces adipocyte differentiation in NIH-PPAR¦Ä cells.
PRICE
54
DESCRIPTION
L-165041 is a potent and selective agonist of the nuclear receptor PPAR?? and PPAR??(Ki = 9 nM, EC50 = ~500 nM ,respectively)
DESCRIPTION
Peroxisome proliferator-activated receptor (PPAR) gamma agonist.
(LOPAC library)
DESCRIPTION
L-165041 is a cell permeable PPARδ agonist which induces adipocyte differentiation in NIH-PPARδ cells. It displays more than 100-fold selectivity for both mouse and human PPARδ receptors over other subtypes. It reduces lipid accumulation in the liver and decreases total hepatic cholesterol and triglyceride content. It also raises plasma cholesterol levels in vivo, in insulin-resistant db/db mice.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
L-165041 is a potent and selective agonist of the nuclear receptor PPARβ and PPARδ(Ki = 9 nM, EC50 = ~500 nM ,respectively)
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
17
AdooQ Bioactive Compound Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugMAP
EU-OPENSCREEN Bioactive Compound Library
EUbOPEN Chemogenomics Library
Guide to Pharmacology
LOPAC library
Mcule NIBR MoA Box Subset
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
NURSA ligand set
TargetMol Bioactive Compound Library
ZINC Tool Compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
26
Molecular Weight
402.17
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
2
Rotatable Bonds
12
Ring Count
2
Aromatic Ring Count
2
cLogP
3.86
TPSA
102.29
Fraction CSP3
0.36
Chiral centers
0.0
Largest ring
6.0
QED
0.41
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
PPAR-gamma
Target
PPAR
PPARD
Member status
member
MOA
PPARdelta Agonists
PPAR receptor agonist
Pathway
DNA Damage/DNA Repair
Metabolism
Cell Cycle/DNA Damage
Metabolic Enzyme/Protease
Vitamin D Related/Nuclear Receptor
Recommended Cell Concentration
1 uM
Source data
