General
Preferred name
FENRETINIDE
Synonyms
Retinoic acid p-hydroxyanilide ()
4-HPR ()
4-hydroxy(phenyl)retinamide ()
MK-4016 ()
Fenretinide (NSC 374551) ()
4-hydroxy(phenyl)retinamide, 4-HPR, MK-4016 ()
MCN-R-1967 ()
Retinamide, n-(4-hydroxyphenyl)- ()
N-(4-hydroxyphenyl)retinamide ()
NSC-760419 ()
All-trans-4'-hydroxyretinanilide ()
Rii retinamide ()
Fenretinide-d4 ()
P&D ID
PD002707
CAS
65646-68-6
2118244-64-5
Tags
drug candidate
natural product
available
Drug indication
Peripheral T-cell lymphoma
Antineoplastic
Macular degeneration
Tumour
Lymphoma
Solid tumour/cancer
Drug Status
investigational
Max Phase
Phase 3
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Vitamin A acid analog with antiproliferative activity in cultured human breast cancer cells (LOPAC library)
DESCRIPTION Subtype-selective ERalpha agonist (Tocris Bioactive Compound Library)
DESCRIPTION Synthetic retinoid. Potent anticancer agent (Tocriscreen Total)
Cell lines
13
Organisms
4
Compound Sets
17
AdooQ Bioactive Compound Library
A12163
Cayman Chemical Bioactives
17688
26489
ChEMBL Drugs
CHEMBL7301
Drug Repurposing Hub
DrugBank
DB05076
DrugMAP
DMRD5SP
EU-OPENSCREEN Bioactive Compound Library
EOS100521
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL7301
MedChem Express Bioactive Compound Library
HY-15373
NPC Screening Collection
Pandemic Response Box
ReFrame library
Selleckchem Bioactive Compound Library
fenretinide
TargetMol Bioactive Compound Library
T1872
Tocris Bioactive Compound Library
1396
Tocriscreen Total
External IDs
32
Properties
(calculated by RDKit )
Molecular Weight
391.25
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
6
Ring Count
2
Aromatic Ring Count
1
cLogP
6.86
TPSA
49.33
Fraction CSP3
0.35
Chiral centers
0.0
Largest ring
6.0
QED
0.32
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Metabolism
Autophagy
Metabolic Enzyme/Protease
Vitamin D Related/Nuclear Receptor
Target
RAR/RAX
RARA
RAR/RXR
Retinoid Receptor
Primary Target
Retinoic Acid Receptors
MOA
apoptosis stimulant, retinoid receptor agonist
Source data