General
Preferred name
BAY 11-7082
Synonyms
Bay 11-7821 ()
BAY11-7082 ()
P&D ID
PD002682
CAS
19542-67-7
1424-48-2
Tags
available
covalent binder
nuisance
drug candidate
Drug indication
Multiple myeloma
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION BAY 11-7082 has long been reported as a NF-κB inhibitor, which inhibits TNFα-induced IκBα phosphorylation (IC50 10μM) . However, an alternative report suggests that BAY 11-7082 reduces the activation of IκB kinases by targeting components of the ubiquitin system, and that this is responsible for its anti-inflammatory effects and induction of B-cell lymphoma and leukaemic T-cell death (GtoPdb)
DESCRIPTION BAY 11-7082 is an I¦ÊB¦Á phosphorylation and NF-¦ÊB inhibitor. BAY 11-7082 selectively and irreversibly inhibits the TNF-¦Á-induced phosphorylation of I¦ÊB-¦Á, and decreases NF-¦ÊB and expression of adhesion molecules. BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21 (IC50=0.19, 0.96 ¦ÌM, respectively). BAY 11-7082 inhibits gasdermin D (GSDMD) pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1¦Â secretion in human and mouse cells[1][2][3][4][5].
PRICE 35
DESCRIPTION BAY 11-7082 (BAY 11-7821) is an NF-??B inhibitor that suppresses TNF??-induced I??B?? phosphorylation (IC50=10 ??M) and also inhibits the ubiquitin-specific proteases USP7 and USP21 (IC50=0.19/0.96 ??M).
DESCRIPTION Inhibitor of cytokine-induced IKB-alpha phosphorylation (LOPAC library)
DESCRIPTION Irreversible inhibitor of TNF-α-induced IκBα phosphorylation (Tocriscreen Total)
DESCRIPTION BAY 11-7082 completely and specifically abrogates NF-κB DNA binding, downregulating the NF-κB-inducible cytokine IL-6 and inducing apoptosis. (BOC Sciences Bioactive Compounds)
DESCRIPTION Proteasome and calpain inhibitor. Inhibits NF-kappaB activation (Tocris Bioactive Compound Library)
DESCRIPTION BAY 11-7082 (BAY 11-7821) is an NF-κB inhibitor that suppresses TNFα-induced IκBα phosphorylation (IC50=10 μM) and also inhibits the ubiquitin-specific proteases USP7 and USP21 (IC50=0.19/0.96 μM). (TargetMol Bioactive Compound Library)
Cell lines
4
Organisms
0
Compound Sets
16
AdooQ Bioactive Compound Library
A11957
Axon Medchem Screening Library
2132
BOC Sciences Bioactive Compounds
bay-11-7082-cas-19542-67-7-352890
Cayman Chemical Bioactives
10010266
CovBinderInPDB
CBR001941
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugMAP
DMQNOFA
Guide to Pharmacology
5934
LOPAC library
MedChem Express Bioactive Compound Library
HY-13453
Nuisance compounds in cellular assays
Selleckchem Bioactive Compound Library
bay-11-7082-bay-11-7821
TargetMol Bioactive Compound Library
T1902
Tocris Bioactive Compound Library
1744
Tocriscreen Total
External IDs
28
Properties
(calculated by RDKit )
Molecular Weight
207.04
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
0
Rotatable Bonds
2
Ring Count
1
Aromatic Ring Count
1
cLogP
1.81
TPSA
57.93
Fraction CSP3
0.1
Chiral centers
0.0
Largest ring
6.0
QED
0.69
Structural alerts
1
Nonspecific/NOS
Nuisance compounds
Related compounds
Custom attributes
(extracted from source data)
Selectivity
IKB-alpha
Target
NF-¦ÊB
NF-??
I??/IKK
RELA
IKK inhibitor
Deubiquitinase
IKK
Apoptosis related,DUB,I¦ÊB/IKK
E2-conjugating enzymes
IκBα phosphorylation
Primary Target
Ubiquitin/Ubl E2 Conjugating Enzymes
MOA
Inhibitor
NFkB pathway inhibitor
Pathway
Apoptosis
Autophagy
Cell Cycle/Checkpoint
DNA Damage/DNA Repair
NF-κB
Ubiquitination
Cell Cycle/DNA Damage
Source data