General
Preferred name
PD-98059
Synonyms
PD 98059 ()
PD 98,059 ()
PD98059 ()
PD-098059 ()
P&D ID
PD002681
CAS
167869-21-8
Tags
available
drug candidate
Drug indication
Cardiac arrest
Drug Status
investigational
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION PD98059 is a non-ATP competitive MEK inhibitor i.e. it acts as a negative allosteric modulator . (GtoPdb)
DESCRIPTION Specific inhibitor of the activation of mitogen-activated protein kinase kinase (MAPKK) (LOPAC library)
DESCRIPTION MEK inhibitor (Tocriscreen Plus)
DESCRIPTION Potent, selective inhibitor of PDGFRbeta (Tocris Bioactive Compound Library)
DESCRIPTION Specific inhibitor of MEK (Tocriscreen Total)
Cell lines
1
Organisms
2
Compound Sets
19
AdooQ Bioactive Compound Library
A10705
Axon Medchem Screening Library
1223
Cayman Chemical Bioactives
10006726
Drug Repurposing Hub
DrugBank
DB17042
DrugMAP
DMZC90M
DrugMatrix
Guide to Pharmacology
5241
JUMP-Target 1 Compound Set
4713
LINCS compound set
10271-101
LOPAC library
MedChem Express Bioactive Compound Library
HY-12028
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
Selleckchem Bioactive Compound Library
PD-98059
TargetMol Bioactive Compound Library
T2623
Tocris Bioactive Compound Library
1213
Tocriscreen Plus
1213
Tocriscreen Total
External IDs
34
Properties
(calculated by RDKit )
Molecular Weight
267.09
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
2
Ring Count
3
Aromatic Ring Count
3
cLogP
3.05
TPSA
65.46
Fraction CSP3
0.06
Chiral centers
0.0
Largest ring
6.0
QED
0.72
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Enzymes
Selectivity
MEK2
Pathway
MAPK
Autophagy
Immunology/Inflammation
MAPK/ERK Pathway
Stem Cell/Wnt
Target
MEK1
AKT1, CHEK1, GSK3B, LCK, MAP2K1, MAPK1, MAPK11, MAPK12, MAPK14, MAPK8, PRKCA, RAF1, ROCK1, RPS6KB1, SGK1
BRAF
Aryl hydrocarbon receptor
ERK
AhR,MEK
Primary Target
MEK
MOA
Inhibitor
ERK1 Inhibitors
MEK1 Inhibitors
MEK2 Inhibitors
MKK4 Inhibitors
MEK inhibitor
Member status
member
Source data