General
Preferred name
CORTODOXONE
Synonyms
CORTEXOLONE ()
11-deoxycortisol ()
11-Desoxycortisol ()
17??,21-dihydroxyprogesterone ()
Reichstein's substance S ()
11-Deoxycortisol, cortexolone, 11-Desoxycortisol, 17α,21-dihydroxyprogesterone ()
17¦Á,21-dihydroxyprogesterone ()
11-Deoxycortisol, cortexolone, 11-Desoxycortisol, 17??,21-dihydroxyprogesterone ()
11-Deoxycortisol, cortexolone, 11-Desoxycortisol, 17¦Á,21-dihydroxyprogesterone ()
17.alpha.-hydroxycortexone ()
Skf-3050 ()
Cortexolone ()
Substance s ()
NSC-18317 ()
SK&F 3050 ()
17,21-dihydroxyprogesterone ()
11-deoxyhydrocortisone ()
Cortifen ()
Cortisol, 11-deoxy- ()
17-hydroxy-11-deoxycorticosterone ()
11-Deoxycortisol ()
11-deoxycortisone ()
P&D ID
PD002678
CAS
152-58-9
Tags
drug candidate
natural product
available
Drug Status
investigational
Max Phase
Phase 2
Drug indication
Anti-Inflammatory
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Precursor of cortisol biosynthesis
(LOPAC library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
9
ChEMBL Drugs
Drug Repurposing Hub
Guide to Pharmacology
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
NPC Screening Collection
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
66
Molecular Weight
346.21
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
2
Ring Count
4
Aromatic Ring Count
0
cLogP
2.81
TPSA
74.6
Fraction CSP3
0.81
Chiral centers
6.0
Largest ring
6.0
QED
0.81
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
Cortisol
Pathway
Metabolism
Immunology/Inflammation
Metabolic Enzyme/Protease
Vitamin D Related/Nuclear Receptor
Target
Glucocorticoid Receptor
AR
Endogenous Metabolite
MOA
Androgen Receptor antagonist
Source data
